Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.

Anti-Bacterial Agents / pharmacology Bacterial Proteins / antagonists & inhibitors Biological Transport / drug effects Cell Wall / drug effects Drug Resistance, Bacterial / genetics Humans Membrane Transport Proteins / genetics Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis / drug effects Tuberculosis / microbiology
antibiotic resistance cell wall drug discovery mechanism of resistance mode of action mycobacteria mycolic acids

Journal

mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533

Informations de publication

Date de publication:
14 10 2020
Historique:
entrez: 15 10 2020
pubmed: 16 10 2020
medline: 21 7 2021
Statut: epublish

Résumé

The

Identifiants

DOI: 10.1128/mSphere.00985-20 PMID: 33055263 PMC: PMC7565900
pubmed: 33055263
pii: 5/5/e00985-20
doi: 10.1128/mSphere.00985-20
pmc: PMC7565900
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Membrane Transport Proteins 0
MmpL3 protein, Mycobacterium tuberculosis 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 McNeil et al.

Références

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Auteurs

Matthew B McNeil (MB)

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.

Theresa O'Malley (T)

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.

Devon Dennison (D)

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.

Catherine D Shelton (CD)

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.

Bjorn Sunde (B)

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.

Tanya Parish (T)

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA tanya.parish@seattlechildrens.org.
Seattle Children's Research Institute, Seattle, Washington, USA.
ORCID: 0000-0001-7507-0423

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Métabolisme › Transport biologique › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Cellules › Structures cellulaires › Paroi cellulaire › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Multiple Mutations in Mycobacterium...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Multiple Mutations in Mycobacterium...