Thrombocytopenia Caused by Dexamethasone in a Patient with Colorectal Cancer.
Adenocarcinoma
/ drug therapy
Aged
Antiemetics
/ adverse effects
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Chemotherapy, Adjuvant
Dexamethasone
/ adverse effects
Female
Humans
Male
Neoplasm Recurrence, Local
Rectal Neoplasms
/ drug therapy
Thrombocytopenia
/ chemically induced
dexamethasone
drug-induced immune thrombocytopenia
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
20
2
2021
Statut:
ppublish
Résumé
Drug-induced immune thrombocytopenia (DITP) is an important cause of thrombocytopenia. A 73-year-old man with relapsed rectal carcinoma received S-1, oxaliplatin and bevacizumab combination therapy (SOX+Bev). Dexamethasone was administered as an antiemetic prophylaxis. On day 2 of the first cycle, thrombocytopenia (8,000/μL) was observed. We sequentially omitted any drugs suspected to possibly induce thrombocytopenia and confirmed dexamethasone as the cause of thrombocytopenia. DITP induced by synthetic corticosteroids is very rare and this is the first case report of DITP induced by dexamethasone. Although rare, DITP due to synthetic corticosteroids including dexamethasone should be a differential diagnosis among patients receiving synthetic corticosteroids with thrombocytopenia.
Identifiants
pubmed: 33055471
doi: 10.2169/internalmedicine.4785-20
pmc: PMC7662045
doi:
Substances chimiques
Antiemetics
0
Dexamethasone
7S5I7G3JQL
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2571-2575Références
Blood. 1991 Jun 15;77(12):2668-76
pubmed: 1710517
J Gerontol A Biol Sci Med Sci. 2002 Aug;57(8):M519-20
pubmed: 12145365
J Pharm Pract. 2014 Oct;27(5):430-9
pubmed: 25134884
Ann Intern Med. 1998 Dec 1;129(11):886-90
pubmed: 9867731
N Engl J Med. 2007 Aug 9;357(6):580-7
pubmed: 17687133
Blood. 2003 Sep 1;102(5):1670-7
pubmed: 12738668
Hematology Am Soc Hematol Educ Program. 2009;:153-8
pubmed: 20008194
J Thromb Haemost. 2013 Jan;11(1):169-76
pubmed: 23121994
Ann Med Interne (Paris). 1994;145(5):357-60
pubmed: 7985949
Blood. 2010 Jul 1;115(26):5431-2
pubmed: 20595525
Drug Saf. 2004;27(15):1243-52
pubmed: 15588119
Blood. 2018 Mar 29;131(13):1486-1489
pubmed: 29439950
DICP. 1990 Jul-Aug;24(7-8):693-5
pubmed: 1695793
Transfus Med Rev. 2013 Jul;27(3):137-45
pubmed: 23845922