A multistate model of survival prediction and event monitoring in prefibrotic myelofibrosis.
Journal
Blood cancer journal
ISSN: 2044-5385
Titre abrégé: Blood Cancer J
Pays: United States
ID NLM: 101568469
Informations de publication
Date de publication:
14 10 2020
14 10 2020
Historique:
received:
06
07
2020
accepted:
18
09
2020
revised:
16
09
2020
pubmed:
16
10
2020
medline:
7
5
2021
entrez:
15
10
2020
Statut:
epublish
Résumé
Among 382 patients with WHO-defined prefibrotic myelofibrosis (pre-PMF) followed for a median of 6.9 years, fibrotic or leukemic transformation or death accounts for 15, 7, and 27% of cases, respectively. A multistate model was applied to analyze survival data taking into account intermediate states that are part of the clinical course of pre-PMF, including overt PMF and acute myeloid leukemia (AML). Within this multistate framework, multivariable models disclosed older age (>65 years) and leukocytosis (>15 × 10
Identifiants
pubmed: 33056979
doi: 10.1038/s41408-020-00368-1
pii: 10.1038/s41408-020-00368-1
pmc: PMC7566465
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)
ID : MYNERVA project, #21267
Pays : International
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