Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France.
Adult
Antibodies, Viral
/ blood
Betacoronavirus
/ genetics
COVID-19
COVID-19 Testing
COVID-19 Vaccines
Clinical Laboratory Techniques
Coronavirus Infections
/ diagnosis
Female
Humans
Immunoglobulin G
/ blood
Pandemics
/ prevention & control
Paris
/ epidemiology
Parturition
Pneumonia, Viral
/ diagnosis
Pregnancy
Pregnancy Complications, Infectious
/ epidemiology
Prospective Studies
Quarantine
/ methods
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Seroepidemiologic Studies
Serologic Tests
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
07
2020
accepted:
02
10
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
3
11
2020
Statut:
epublish
Résumé
To fight the COVID-19 pandemic, lockdown has been decreed in many countries worldwide. The impact of pregnancy as a severity risk factor is still debated, but strict lockdown measures have been recommended for pregnant women. To evaluate the impact of the COVID-19 pandemic and lockdown on the seroprevalence and circulation of SARS-CoV-2 in a maternity ward in an area that has been significantly affected by the virus. Prospective study at the Antoine Béclère Hospital maternity ward (Paris area, France) from May 4 (one week before the end of lockdown) to May 31, 2020 (three weeks after the end of lockdown). All patients admitted to the delivery room during this period were offered a SARS-CoV-2 serology test as well concomitant SARS-CoV-2 RT-PCR on one nasopharyngeal sample. A total of 249 women were included. Seroprevalence of SARS-CoV-2 was 8%. The RT-PCR positive rate was 0.5%. 47.4% of the SARS-CoV-2-IgG-positive pregnant women never experienced any symptoms. A history of symptoms during the epidemic, such as fever (15.8%), myalgia (36.8%) and anosmia (31.6%), was suggestive of previous infection. Three weeks after the end of French lockdown, SARS-CoV-2 infections were scarce in our region. A very high proportion of SARS-CoV-2-IgG-negative pregnant women, which is comparable to that of the general population, must be taken into consideration in the event of a resurgence of the pandemic. The traces of a past active circulation of the virus in this fragile population during the spring wave should encourage public health authorities to take specific measures for this independent at-risk group, in order to reduce viral circulation in pregnant patients.
Sections du résumé
BACKGROUND
To fight the COVID-19 pandemic, lockdown has been decreed in many countries worldwide. The impact of pregnancy as a severity risk factor is still debated, but strict lockdown measures have been recommended for pregnant women.
OBJECTIVES
To evaluate the impact of the COVID-19 pandemic and lockdown on the seroprevalence and circulation of SARS-CoV-2 in a maternity ward in an area that has been significantly affected by the virus.
STUDY DESIGN
Prospective study at the Antoine Béclère Hospital maternity ward (Paris area, France) from May 4 (one week before the end of lockdown) to May 31, 2020 (three weeks after the end of lockdown). All patients admitted to the delivery room during this period were offered a SARS-CoV-2 serology test as well concomitant SARS-CoV-2 RT-PCR on one nasopharyngeal sample.
RESULTS
A total of 249 women were included. Seroprevalence of SARS-CoV-2 was 8%. The RT-PCR positive rate was 0.5%. 47.4% of the SARS-CoV-2-IgG-positive pregnant women never experienced any symptoms. A history of symptoms during the epidemic, such as fever (15.8%), myalgia (36.8%) and anosmia (31.6%), was suggestive of previous infection.
CONCLUSIONS
Three weeks after the end of French lockdown, SARS-CoV-2 infections were scarce in our region. A very high proportion of SARS-CoV-2-IgG-negative pregnant women, which is comparable to that of the general population, must be taken into consideration in the event of a resurgence of the pandemic. The traces of a past active circulation of the virus in this fragile population during the spring wave should encourage public health authorities to take specific measures for this independent at-risk group, in order to reduce viral circulation in pregnant patients.
Identifiants
pubmed: 33057392
doi: 10.1371/journal.pone.0240782
pii: PONE-D-20-20995
pmc: PMC7561105
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Covid-19 aAPC vaccine
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0240782Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Gynecol Obstet Hum Reprod. 2020 Sep;49(7):101826
pubmed: 32505805
Lancet. 2020 Aug 1;396(10247):313-319
pubmed: 32534626
Am J Obstet Gynecol. 2020 Jun 15;:
pubmed: 32553908
J Gynecol Obstet Hum Reprod. 2020 Sep;49(7):101804
pubmed: 32407897
Front Med. 2020 Apr;14(2):193-198
pubmed: 32285380
Lancet. 2020 Aug 22;396(10250):530-531
pubmed: 32771084
MMWR Morb Mortal Wkly Rep. 2020 Jun 26;69(25):769-775
pubmed: 32584795
EClinicalMedicine. 2020 Aug;25:100446
pubmed: 32838230
JAMA. 2020 Jun 16;323(23):2425-2427
pubmed: 32421144
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
AJR Am J Roentgenol. 2020 Jul;215(1):127-132
pubmed: 32186894
Am J Obstet Gynecol. 2020 Jul 27;:
pubmed: 32730899
Nat Commun. 2020 Jul 14;11(1):3572
pubmed: 32665677
Science. 2020 Jul 10;369(6500):208-211
pubmed: 32404476
Am J Obstet Gynecol. 2020 Jul;223(1):109.e1-109.e16
pubmed: 32360108
BJOG. 2020 Nov;127(12):1548-1556
pubmed: 32633022