7-T MRI of explanted liver and ex-vivo pancreatic specimens: prospective study protocol of radiological-pathological correlation feasibility (the EXLIPSE project).
Liver cirrhosis
Liver steatosis
Liver transplantation
Magnetic resonance imaging
Pancreatic neoplasms
Journal
European radiology experimental
ISSN: 2509-9280
Titre abrégé: Eur Radiol Exp
Pays: England
ID NLM: 101721752
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
received:
15
04
2020
accepted:
03
09
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
6
7
2021
Statut:
epublish
Résumé
The study focuses on radiological-pathological correlation between imaging of ex vivo samples obtained by a 7-T scanner and histological examination. The specimens will be derived from native explanted cirrhotic livers, liver grafts excluded from donation because of severe steatosis, and primary pancreatic tumours. Magnetic resonance imaging (MRI) examinations will be performed within 24 h from liver or pancreatic lesion surgical removal. The MRI protocol will include morphological sequences, quantitative T1, T2, and fat-, water-fraction maps with Cartesian k-space acquisition, and multiparametric methods based on a transient-state "MRI fingerprinting". Finally, the specimen will be fixed by formalin. Qualitative imaging analysis will be performed by two independent blinded radiologists to assess image consistency score. Quantitative analysis will be performed by drawing regions of interest on different tissue zones to measure T1 and T2 relaxation times as well as fat- and water-fraction. The same tissue areas will be analysed by the pathologists. This study will provide the possibility to improve our knowledge about qualitative and quantitative abdominal imaging assessment at 7 T, by correlating imaging characteristics and the corresponding histological composition of ex vivo specimens, in order to identify imaging biomarkers. Trial registration: ClinicalTrials.gov : 13646. Registered 9 July 2019-retrospectively registered.
Identifiants
pubmed: 33057851
doi: 10.1186/s41747-020-00185-y
pii: 10.1186/s41747-020-00185-y
pmc: PMC7560686
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
58Références
Magn Reson Med. 2017 Feb;77(2):774-778
pubmed: 26888162
Magn Reson Med. 2005 Aug;54(2):324-32
pubmed: 16032673
BMC Cancer. 2009 Nov 13;9:395
pubmed: 19912635
Liver Transpl. 2010 Dec;16(12):1393-9
pubmed: 21117249
Nature. 2013 Mar 14;495(7440):187-92
pubmed: 23486058
Br J Radiol. 2018 Dec;91(1092):20170825
pubmed: 29975154
Mt Sinai J Med. 2012 Mar-Apr;79(2):169-89
pubmed: 22499489
HPB (Oxford). 2012 Sep;14(9):635-45
pubmed: 22882201
Top Magn Reson Imaging. 2017 Dec;26(6):229-241
pubmed: 28858038
Hepatology. 2020 Mar;71(3):943-954
pubmed: 31344273
Magn Reson Med. 2016 Feb;75(2):801-9
pubmed: 25820458
Phys Med. 2017 Jun;38:122-139
pubmed: 28595812
J Gastroenterol Hepatol. 2012 Mar;27(3):540-6
pubmed: 21777274
Magn Reson Med. 2005 Sep;54(3):636-44
pubmed: 16092103
Liver Transpl. 2008 Dec;14(12):1694-707
pubmed: 19025925
Magn Reson Med. 2006 Oct;56(4):927-31
pubmed: 16941621
J Hepatol. 2011 May;54(5):1055-62
pubmed: 21145846
Magn Reson Med. 2019 May;81(5):3032-3045
pubmed: 30578569
Eur Radiol Exp. 2018 Oct 3;2(1):25
pubmed: 30280310
Histopathology. 2020 Jan;76(2):182-188
pubmed: 31433515
Br J Radiol. 2019 Jul;92(1099):20180941
pubmed: 30982337
Hepatology. 2005 Jun;41(6):1313-21
pubmed: 15915461
Neuroimage. 2010 Jan 15;49(2):1271-81
pubmed: 19819338
Eur Radiol. 2019 Feb;29(2):509-516
pubmed: 30043161
J Magn Reson Imaging. 2015 Jan;41(1):13-33
pubmed: 24478137
BMC Cancer. 2009 Dec 26;9:463
pubmed: 20035626
Hepatology. 2018 Aug;68(2):763-772
pubmed: 29356032
Radiology. 2016 Apr;279(1):278-86
pubmed: 26794935
Br J Surg. 2006 Oct;93(10):1232-7
pubmed: 16804874
Magn Reson Med. 2009 Jul;62(1):26-34
pubmed: 19353660
Eur J Radiol. 2017 Aug;93:30-39
pubmed: 28668428