Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles.
Animals
Bone Morphogenetic Proteins
/ metabolism
Cell Differentiation
/ physiology
Chemokines
/ metabolism
Ear Ossicles
/ growth & development
Ear, Middle
/ growth & development
Fibroblast Growth Factors
/ metabolism
Humans
Neural Crest
/ metabolism
Signal Transduction
/ physiology
Transcription Factors
/ metabolism
columella
growth factors
incus
malleus
middle ear
neural crest cells
ossicle
stapes
transcription factors
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Titre abrégé: Dev Dyn
Pays: United States
ID NLM: 9201927
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
12
08
2020
revised:
11
10
2020
accepted:
11
10
2020
pubmed:
16
10
2020
medline:
3
11
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
The mammalian middle ear comprises a chain of ossicles, the malleus, incus, and stapes that act as an impedance matching device during the transmission of sound from the tympanic membrane to the inner ear. These ossicles are derived from cranial neural crest cells that undergo endochondral ossification and subsequently differentiate into their final functional forms. Defects that occur during middle ear development can result in conductive hearing loss. In this review, we summarize studies describing the crucial roles played by signaling molecules such as sonic hedgehog, bone morphogenetic proteins, fibroblast growth factors, notch ligands, and chemokines during the differentiation of neural crest into the middle ear ossicles. In addition to these cell-extrinsic signals, we also discuss studies on the function of transcription factor genes such as Foxi3, Tbx1, Bapx1, Pou3f4, and Gsc in regulating the development and morphology of the middle ear ossicles.
Identifiants
pubmed: 33058336
doi: 10.1002/dvdy.260
pmc: PMC8515770
mid: NIHMS1745249
doi:
Substances chimiques
Bone Morphogenetic Proteins
0
Chemokines
0
Transcription Factors
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1410-1424Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC013072
Pays : United States
Organisme : National Institutes of Health:
ID : DC013072
Informations de copyright
© 2020 American Association of Anatomists.
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