Opsin 3-G
Animals
Cells, Cultured
Cyclic AMP
/ metabolism
Cyclic AMP-Dependent Protein Kinases
/ metabolism
G-Protein-Coupled Receptor Kinase 2
/ metabolism
Humans
Male
Mice
Mice, Inbred C57BL
Muscle Relaxation
/ physiology
Muscle, Smooth
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
Opsins
/ metabolism
Rod Opsins
/ metabolism
Signal Transduction
/ physiology
Trachea
/ metabolism
OPN1LW
OPN3
blue light
nonvisual opsin
photorelaxation
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
pubmed:
16
10
2020
medline:
2
2
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
Recently, we characterized blue light-mediated relaxation (photorelaxation) of airway smooth muscle (ASM) and implicated the involvement of opsin 3 (OPN3), an atypical opsin. In the present study, we characterized the cellular signaling mechanisms of photorelaxation. We confirmed the functional role of OPN3 in blue light photorelaxation using trachea from OPN3 null mice (maximal relaxation 52 ± 13% compared with wild-type mice 90 ± 4.3%,
Identifiants
pubmed: 33058732
doi: 10.1165/rcmb.2020-0392OC
pmc: PMC7780995
doi:
Substances chimiques
OPN3 protein, mouse
0
Opsins
0
Rod Opsins
0
Cyclic AMP
E0399OZS9N
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
GRK2 protein, mouse
EC 2.7.11.15
G-Protein-Coupled Receptor Kinase 2
EC 2.7.11.16
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-68Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM065281
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144852
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008464
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM063483
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122340
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL150314
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082251
Pays : United States
Commentaires et corrections
Type : CommentIn
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