Stem cell function and plasticity in the normal physiology of the adrenal cortex.
Adrenal homeostasis
Adrenocortical zonation
Sex-specific renewal
Sonic hedgehog
Stem cell function
Wnt/β-catenin
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
27
06
2020
revised:
07
09
2020
accepted:
28
09
2020
pubmed:
16
10
2020
medline:
28
7
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and necessitate a precise steroidogenic response. To meet these diverse needs, the adrenal employs multiple cell populations with stem cell function. Here, we discuss the literature on adrenocortical stem cells using hematopoietic stem cells as a benchmark to examine the functional capacity of particular cell populations, including those located in the capsule and peripheral cortex. These populations are coordinately regulated by paracrine and endocrine signaling mechanisms, and display remarkable plasticity to adapt to different physiological and pathological conditions. Some populations also exhibit sex-specific activity, which contributes to highly divergent proliferation rates between sexes. Understanding mechanisms that govern adrenocortical renewal has broad implications for both regenerative medicine and cancer.
Identifiants
pubmed: 33058950
pii: S0303-7207(20)30345-2
doi: 10.1016/j.mce.2020.111043
pmc: PMC7736543
mid: NIHMS1640956
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111043Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK062027
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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