Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche.
Animals
Bone Marrow Cells
/ cytology
Cell Communication
/ physiology
Cell Differentiation
/ physiology
Cell Proliferation
/ physiology
Cellular Microenvironment
/ physiology
Exosomes
/ metabolism
Extracellular Vesicles
/ metabolism
Hematopoietic Stem Cells
/ cytology
Humans
Mesenchymal Stem Cells
/ cytology
Neoplasms
/ pathology
Tumor Microenvironment
/ physiology
Bone marrow niche
Exosome
Extracellular vehicles
Hematopoietic stem cell
Mesenchymal stem cells
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
18
08
2020
revised:
26
09
2020
accepted:
04
10
2020
pubmed:
16
10
2020
medline:
20
2
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) have been regarded as important tools for cell-cell communication. They act as carriers for the transfer of various molecules such as genes, proteins and miRNA. EVs shift and transfer their ingredients to target cells in an active form. These particles have prominent roles in modulation of bone marrow (BM) niche; therefore they can regulate proliferation, differentiation, and other properties of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). This review discusses the different roles of EVs on BM niche; HPCs fate regulation and downstream effects of them on HSCs. Moreover, cellular and molecular mechanisms of BM microenvironment cross-talking are explained in healthy and malignant settings.
Identifiants
pubmed: 33059261
pii: S0753-3322(20)31046-5
doi: 10.1016/j.biopha.2020.110854
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110854Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.