Loss of USF2 promotes proliferation, migration and mitophagy in a redox-dependent manner.
Compromised mitochondria
Migration
Mitophagy
Proliferation
Upstream stimulatory factor 2 (USF2)
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
28
08
2020
revised:
02
10
2020
accepted:
04
10
2020
pubmed:
16
10
2020
medline:
22
6
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
The upstream stimulatory factor 2 (USF2) is a transcription factor implicated in several cellular processes and among them, tumor development seems to stand out. However, the data with respect to the role of USF2 in tumor development are conflicting suggesting that it acts either as tumor promoter or suppressor. Here we show that absence of USF2 promotes proliferation and migration. Thereby, we reveal a previously unknown function of USF2 in mitochondrial homeostasis. Mechanistically, we demonstrate that deficiency of USF2 promotes survival by inducing mitophagy in a ROS-sensitive manner by activating both ERK1/2 and AKT. Altogether, this study supports USF2's function as tumor suppressor and highlights its novel role for mitochondrial function and energy homeostasis thereby linking USF2 to conditions such as insulin resistance, type-2 diabetes mellitus, and the metabolic syndrome.
Identifiants
pubmed: 33059314
pii: S2213-2317(20)30955-1
doi: 10.1016/j.redox.2020.101750
pmc: PMC7566946
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101750Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.
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