Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects.


Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907

Informations de publication

Date de publication:
02 2021
Historique:
received: 10 06 2020
accepted: 26 09 2020
revised: 18 09 2020
pubmed: 16 10 2020
medline: 24 6 2021
entrez: 15 10 2020
Statut: ppublish

Résumé

Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric research and therapy. However, no modern studies have evaluated subjective and autonomic effects of different and pharmaceutically well-defined doses of LSD. We used a double-blind, randomized, placebo-controlled, crossover design in 16 healthy subjects (eight women, eight men) who underwent six 25 h sessions and received placebo, LSD (25, 50, 100, and 200 µg), and 200 µg LSD 1 h after administration of the serotonin 5-hydroxytryptamine-2A (5-HT

Identifiants

pubmed: 33059356
doi: 10.1038/s41386-020-00883-6
pii: 10.1038/s41386-020-00883-6
pmc: PMC8027607
doi:

Substances chimiques

Hallucinogens 0
Lysergic Acid Diethylamide 8NA5SWF92O
Ketanserin 97F9DE4CT4

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

537-544

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Auteurs

Friederike Holze (F)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Patrick Vizeli (P)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Laura Ley (L)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Felix Müller (F)

Psychiatric University Hospital, University of Basel, Basel, Switzerland.

Patrick Dolder (P)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Melanie Stocker (M)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Urs Duthaler (U)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

Nimmy Varghese (N)

Psychiatric University Hospital, University of Basel, Basel, Switzerland.
Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.

Anne Eckert (A)

Psychiatric University Hospital, University of Basel, Basel, Switzerland.
Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.

Stefan Borgwardt (S)

Psychiatric University Hospital, University of Basel, Basel, Switzerland.

Matthias E Liechti (ME)

Department of Biomedicine and Department of Clinical Research, Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland. matthias.liechti@usb.ch.
Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. matthias.liechti@usb.ch.

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