Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node.
Action Potentials
/ genetics
Animals
Calcium Channels
/ genetics
Gene Expression Profiling
Heart Rate
/ genetics
Humans
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
/ genetics
MicroRNAs
/ genetics
Muscle Proteins
/ genetics
Potassium Channels
/ genetics
RNA, Small Untranslated
/ genetics
Rats
Sinoatrial Node
/ pathology
ion channels
microRNAs
pacemaker of the heart
sinus node disease
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
20 10 2020
20 10 2020
Historique:
pubmed:
17
10
2020
medline:
16
3
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca
Identifiants
pubmed: 33059532
doi: 10.1161/JAHA.120.016590
pmc: PMC7763385
doi:
Substances chimiques
Calcium Channels
0
HCN1 protein, human
0
HCN4 protein, human
0
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
0
MIRN486 microRNA, human
0
MicroRNAs
0
Muscle Proteins
0
Potassium Channels
0
RNA, Small Untranslated
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e016590Subventions
Organisme : British Heart Foundation
ID : FS/19/1/34035
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/17/32/32987
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL115580
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135109
Pays : United States
Organisme : British Heart Foundation
ID : RG/18/2/33392
Pays : United Kingdom
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