Triple Artemisinin-Based Combination Therapies for Malaria - A New Paradigm?
ACT
P. falciparum
TACT
artemisinin
malaria
resistance
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
13
07
2020
revised:
18
09
2020
accepted:
19
09
2020
pubmed:
17
10
2020
medline:
3
3
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs.
Identifiants
pubmed: 33060063
pii: S1471-4922(20)30254-3
doi: 10.1016/j.pt.2020.09.011
pii:
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-24Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.