Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin.

Carcinoma, Pancreatic Ductal / etiology Cell Transformation, Neoplastic / genetics CpG Islands DNA Methylation Disease Progression Disease Susceptibility Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Interferons / metabolism Models, Biological Pancreatic Neoplasms / etiology Prognosis Repetitive Sequences, Nucleic Acid Reproducibility of Results Signal Transduction Transcriptome Tumor Microenvironment / genetics

Journal

Cancer discovery

ISSN: 2159-8290

Titre abrégé: Cancer Discov

Pays: United States

ID NLM: 101561693

Informations de publication

Date de publication:
03 2021

Historique:

received: 18 08 2020

revised: 24 09 2020

accepted: 25 09 2020

pubmed: 17 10 2020

medline: 20 1 2022

entrez: 16 10 2020

Statut: ppublish

Résumé

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia, which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified epithelial cells from human PDAC and normal pancreas and derived their genome-wide transcriptome and DNA methylome landscapes. Clustering based on DNA methylation revealed two distinct PDAC groups displaying different methylation patterns at regions encoding repeat elements. Methylation

Identifiants

DOI: 10.1158/2159-8290.CD-20-1202 PMID: 33060108 PMC: PMC9216338

pubmed: 33060108

pii: 2159-8290.CD-20-1202

doi: 10.1158/2159-8290.CD-20-1202

pmc: PMC9216338

mid: NIHMS1634719

doi:

Substances chimiques

Interferons 9008-11-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

638-659

Subventions

Organisme : Intramural NIH HHS

ID : ZIA BC011798

Pays : United States

Organisme : CIHR

Pays : Canada

Informations de copyright

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