The nucleus acts as a ruler tailoring cell responses to spatial constraints.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
16 10 2020
16 10 2020
Historique:
received:
20
11
2019
revised:
29
06
2020
accepted:
28
08
2020
entrez:
16
10
2020
pubmed:
17
10
2020
medline:
28
10
2020
Statut:
ppublish
Résumé
The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.
Identifiants
pubmed: 33060332
pii: 370/6514/eaba2894
doi: 10.1126/science.aba2894
pmc: PMC8059074
mid: NIHMS1689436
pii:
doi:
Substances chimiques
MYH9 protein, human
0
Actomyosin
9013-26-7
Myosin Heavy Chains
EC 3.6.4.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133522
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126054
Pays : United States
Organisme : NCI NIH HHS
ID : K25 CA204526
Pays : United States
Organisme : NIGMS NIH HHS
ID : K99 GM123221
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA235254
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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