Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.
Animals
Antimicrobial Cationic Peptides
/ metabolism
Bacteria
/ immunology
Fatty Acids
/ metabolism
GTP Phosphohydrolases
/ metabolism
HEK293 Cells
Host-Pathogen Interactions
/ immunology
Humans
Immunity, Innate
Lipid Droplets
/ immunology
Lipopolysaccharides
/ immunology
Macrophages
/ immunology
Male
Mice
Mice, Inbred C57BL
Mitochondria
/ immunology
Cathelicidins
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
16 10 2020
16 10 2020
Historique:
received:
19
07
2019
revised:
29
04
2020
accepted:
21
08
2020
entrez:
16
10
2020
pubmed:
17
10
2020
medline:
28
10
2020
Statut:
ppublish
Résumé
Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.
Identifiants
pubmed: 33060333
pii: 370/6514/eaay8085
doi: 10.1126/science.aay8085
pii:
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Fatty Acids
0
Lipopolysaccharides
0
GTP Phosphohydrolases
EC 3.6.1.-
Cathelicidins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.