Effect of goal-directed therapy on post-operative neutrophil gelatinase-associated lipocalin profile in patients undergoing on-pump coronary artery surgery.
Acute kidney injury
Cardiopulmonary bypass
Goal-directed therapy
Journal
Indian journal of thoracic and cardiovascular surgery
ISSN: 0973-7723
Titre abrégé: Indian J Thorac Cardiovasc Surg
Pays: India
ID NLM: 8700105
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
03
08
2018
revised:
08
10
2018
accepted:
09
10
2018
entrez:
16
10
2020
pubmed:
1
7
2019
medline:
1
7
2019
Statut:
ppublish
Résumé
Neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker of acute kidney injury (AKI). Goal-directed therapy (GDT) in on-pump coronary artery bypass grafting (CABG) has been associated with lower post-operative NGAL levels in recent studies. The present study aimed at comparing plasma (P) and urinary (U)-NGAL levels following the use of GDT versus conventional haemodynamic therapy (CT) in patients undergoing on-pump CABG. A prospective randomised controlled study conducted in a single university hospital. A total of 54 patients in the GDT group and 56 patients in CT group after exclusions. U-NGAL was significantly lower immediately post-surgery ( Haemodynamic optimisation with GDT prevents further renal insult initiated with the inflammatory activation with cardiopulmonary bypass (CPB), as evidenced by lower post-operative U-NGAL levels.
Identifiants
pubmed: 33061029
doi: 10.1007/s12055-018-0758-4
pii: 758
pmc: PMC7525641
doi:
Types de publication
Journal Article
Langues
eng
Pagination
445-452Informations de copyright
© Indian Association of Cardiovascular-Thoracic Surgeons 2018.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
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