Anethole Dithiolethione Increases Glutathione in Kidney by Inhibiting
Anethole Trithione
/ administration & dosage
Animals
Cell Line
Cysteine
/ blood
Dipeptides
/ blood
Disulfides
/ blood
Glutathione
/ blood
Humans
Kidney
/ drug effects
Kidney Tubules, Proximal
/ cytology
Male
Malondialdehyde
/ blood
Oxidative Stress
/ drug effects
Rats
Rats, Sprague-Dawley
gamma-Glutamyltransferase
/ antagonists & inhibitors
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
06
2020
revised:
28
08
2020
accepted:
10
09
2020
entrez:
16
10
2020
pubmed:
17
10
2020
medline:
13
5
2021
Statut:
epublish
Résumé
Anethole dithiolethione (ADT) is a marketed drug to treat xerostomia. Its mechanism of action is still unknown, but several preclinical studies indicate that it is able to increase intracellular glutathione (GSH) and protect against oxidative stress. Here, we investigated the molecular mechanisms behind these effects. Oral treatment of rats confirmed the GSH enhancing properties of ADT; among the different organs examined in this study, only the kidney showed a significant GSH increase that was already observed at low-dose treatments. The increase in GSH correlated with a decrease in s. The prominent
Identifiants
pubmed: 33062138
doi: 10.1155/2020/3562972
pmc: PMC7539083
doi:
Substances chimiques
Dipeptides
0
Disulfides
0
cysteinylglycine
384644SZ9T
Malondialdehyde
4Y8F71G49Q
gamma-Glutamyltransferase
EC 2.3.2.2
Glutathione
GAN16C9B8O
Cysteine
K848JZ4886
Anethole Trithione
QUY32964DJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3562972Informations de copyright
Copyright © 2020 Daniela Giustarini et al.
Déclaration de conflit d'intérêts
The authors declare they have not conflicts of interest.
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