Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration.

Calibration exosomes extracellular vesicles microvesicles optical analysis quality control reference materials standardization validation

Journal

Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479

Informations de publication

Date de publication:
24 Sep 2020
Historique:
entrez: 16 10 2020
pubmed: 17 10 2020
medline: 17 10 2020
Statut: epublish

Résumé

Accurate characterization of extracellular vesicles (EVs) is critical to explore their diagnostic and therapeutic applications. As the EV research field has developed, so too have the techniques used to characterize them. The development of reference materials are required for the standardization of these techniques. This work, initiated from the ISEV 2017 Biomarker Workshop in Birmingham, UK, and with further discussion during the ISEV 2019 Standardization Workshop in Ghent, Belgium, sets out to elucidate which reference materials are required and which are currently available to standardize commonly used analysis platforms for characterizing EV refractive index, epitope abundance, size and concentration. Due to their predominant use among EV researchers, a particular focus is placed on the optical methods nanoparticle tracking analysis and flow cytometry.

Identifiants

DOI: 10.1080/20013078.2020.1816641 PMID: 33062218 PMC: PMC7534292
pubmed: 33062218
doi: 10.1080/20013078.2020.1816641
pii: 1816641
pmc: PMC7534292
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1816641

Subventions

Organisme : NIMH NIH HHS
ID : R21 MH118164
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047807
Pays : United States
Organisme : NIMH NIH HHS
ID : R33 MH118164
Pays : United States
Organisme : NCI NIH HHS
ID : UG3 CA241694
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI144997
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA040385
Pays : United States

Informations de copyright

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

Déclaration de conflit d'intérêts

JAW, JCJ, KWW, ML, RN, ALL, AH report no conflict of interest. MAL is CEO of ViroFlow Technologies, Inc. EvdP is co-founder, CSO and shareholder of Exometry BV.

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Auteurs

Joshua A Welsh (JA)

Translational Nanobiology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, USA.

Edwin van der Pol (E)

Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Biomedical Engineering & Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Britta A Bettin (BA)

Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

David R F Carter (DRF)

Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK.

An Hendrix (A)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University Hospital, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
ORCID: 0000-0002-1883-8309

Metka Lenassi (M)

Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Marc-André Langlois (MA)

University of Ottawa Flow Cytometry and Virometry Core Facility, Ottawa, Canada.
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Ottawa Center for Infection, Immunity and Inflammation, Ottawa, Canada.

Alicia Llorente (A)

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Norway.

Arthur S van de Nes (AS)

VSL Dutch Metrology Institute, Delft, The Netherlands.

Rienk Nieuwland (R)

Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.
Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Vera Tang (V)

University of Ottawa Flow Cytometry and Virometry Core Facility, Ottawa, Canada.
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

Lili Wang (L)

National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA.

Kenneth W Witwer (KW)

Departments of Molecular and Comparative Pathobiology and Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0003-1664-4233

Jennifer C Jones (JC)

Translational Nanobiology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, USA.
ORCID: 0000-0002-9488-7719

Classifications MeSH