Subthreshold Micropulse Laser in Diabetic Macular Edema: 1-Year Improvement in OCT/OCT-Angiography Biomarkers.
diabetic macular edema
inflammation
optical coherence tomography
optical coherence tomography angiography
subthreshold micropulse laser
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
28
05
2020
accepted:
24
08
2020
entrez:
16
10
2020
pubmed:
17
10
2020
medline:
17
10
2020
Statut:
epublish
Résumé
The aim of this study was to evaluate 1-year quantitative changes in specific inflammatory parameters on optical coherence tomography (OCT) / optical coherence tomography angiography (OCTA) in diabetic macular edema (DME) treated with subthreshold micropulse laser (SMPL). Thirty-seven patients / eyes with previously treatment-naïve DME treated with SMPL were prospectively evaluated at 3, 6, and 12 months. Fifteen fellow eyes with only microaneurysms (MAS) not eligible for treatment were controls. Evaluated OCT / OCTA parameters included: central macular thickness (CMT); hyper-reflective retinal spots (HRS); disorganization of inner retinal layers (DRILs); MA in the superficial / deep capillary plexuses (SCP/DCP); cysts in the area at the SCP / DCP; and macular perfusion parameters (MATLAB, version 2017b). In the treated group, mean best corrected visual acuity (BCVA) progressively increased from 69.4 ± 12.0 to 76.0 ± 9.1 Early Treatment Diabetic Retinopathy Study (ETDRS) letters ( SMPL reduced the number of HRS (sign of activated microglia cells in the retina), MA, DRIL extension, and the area of cysts. Further studies are needed to confirm these preliminary data on the anti-inflammatory effect of SMPL, and to explore the mechanism of action. The follow-up of OCT/OCTA noninvasive biomarkers offers a unique insight in the mechanism of laser action, suggesting an anti-inflammatory effect of SMPL.
Identifiants
pubmed: 33062394
doi: 10.1167/tvst.9.10.31
pii: TVST-20-2687
pmc: PMC7533727
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Pagination
31Informations de copyright
Copyright 2020 The Authors.
Déclaration de conflit d'intérêts
Disclosure: S. Vujosevic, None; C. Toma, None; E. Villani, None; M. Brambilla, None; E. Torti, None; F. Leporati, None; A. Muraca, None; P. Nucci, None; S. De Cilla, None
Références
Ophthalmology. 2003 Sep;110(9):1677-82
pubmed: 13129861
Retina. 2015 Aug;35(8):1594-603
pubmed: 25719988
Br J Ophthalmol. 2004 Sep;88(9):1173-9
pubmed: 15317711
N Engl J Med. 2012 Mar 29;366(13):1227-39
pubmed: 22455417
Clin Exp Ophthalmol. 2007 Sep-Oct;35(7):640-4
pubmed: 17894684
Trends Neurosci. 1996 Aug;19(8):307-12
pubmed: 8843598
Retina. 2010 Jun;30(6):908-16
pubmed: 20168272
Sci Rep. 2019 Jul 11;9(1):10034
pubmed: 31296907
Ophthalmic Surg Lasers Imaging Retina. 2018 Nov 1;49(11):e218-e225
pubmed: 30457660
Am J Ophthalmol. 2019 Jul;203:103-115
pubmed: 30689991
Retina. 2014 Oct;34(10):2010-20
pubmed: 24837050
Acta Ophthalmol. 2017 Aug;95(5):464-471
pubmed: 27775223
Am J Ophthalmol. 2017 Jul;179:90-96
pubmed: 28483496
Biomed Pharmacother. 2018 Jan;97:293-299
pubmed: 29091878
Int J Mol Sci. 2017 Jun 02;18(6):
pubmed: 28574436
J Diabetes Res. 2019 Jun 12;2019:2547216
pubmed: 31281849
Br J Ophthalmol. 2005 Jan;89(1):74-80
pubmed: 15615751
Ophthalmology. 2015 Jul;122(7):1375-94
pubmed: 25935789
Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO68-BIO75
pubmed: 28510630
Cochrane Database Syst Rev. 2018 Oct 15;10:CD010859
pubmed: 30320466
Ophthalmol Ther. 2017 Jun;6(1):1-6
pubmed: 28185205
Diabetes. 2015 Jul;64(7):2560-70
pubmed: 25633419
Invest Ophthalmol Vis Sci. 2011 Jun 17;52(7):4314-23
pubmed: 21345996
Curr Med Chem. 2013;20(26):3267-71
pubmed: 23745552
J Ophthalmol. 2015;2015:729792
pubmed: 26697211
Retina. 2020 Feb;40(2):312-321
pubmed: 31972802
Ophthalmology. 2016 Nov;123(11):2368-2375
pubmed: 27613201
Eur J Ophthalmol. 2020 Apr 14;:1120672120915169
pubmed: 32290705
Br J Ophthalmol. 2009 Oct;93(10):1341-4
pubmed: 19054831
Retina. 2017 Jun;37(6):1092-1103
pubmed: 27668929
Curr Diabetes Rev. 2012 Jul 1;8(4):274-84
pubmed: 22587512
JAMA Ophthalmol. 2014 Nov;132(11):1309-16
pubmed: 25058813
Int Ophthalmol. 2019 Aug;39(8):1845-1859
pubmed: 30194547
Cell Biochem Biophys. 2015 Nov;73(2):545-552
pubmed: 27352351
Acta Ophthalmol. 2020 Mar;98(2):e217-e223
pubmed: 31421028
Am J Ophthalmol. 2019 Feb;198:8-16
pubmed: 30308201
Acta Ophthalmol. 2019 Jun;97(4):e540-e544
pubmed: 30318792
Ophthalmic Res. 2015;54(3):112-7
pubmed: 26315448
Retina. 2020 Jan;40(1):126-134
pubmed: 30300267
Acta Diabetol. 2020 Mar;57(3):287-296
pubmed: 31541333
Retina. 2016 Nov;36(11):2059-2065
pubmed: 27096529