Predicting myofiber cross-sectional area and triglyceride content with electrical impedance myography: A study in db/db mice.
LASSO prediction algorithm
electrical impedance myography
muscle triglyceride content
myofiber atrophy
myofiber size
obesity-induced sarcopenia
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
29
04
2020
revised:
02
08
2020
accepted:
11
10
2020
pubmed:
17
10
2020
medline:
20
2
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Electrical impedance myography (EIM) provides insight into muscle composition and structure. We sought to evaluate its use in a mouse obesity model characterized by myofiber atrophy. We applied a prediction algorithm, ie, the least absolute shrinkage and selection operator (LASSO), to surface, needle array, and ex vivo EIM data from db/db and wild-type mice and assessed myofiber cross-sectional area (CSA) histologically and triglyceride (TG) content biochemically. EIM data from all three modalities provided acceptable predictions of myofiber CSA with average root mean square error (RMSE) of 15% in CSA (ie, ±209 μm EIM combined with a predictive algorithm provides reasonable estimates of myofiber CSA and TG content without the need for biopsy.
Sections du résumé
BACKGROUND
Electrical impedance myography (EIM) provides insight into muscle composition and structure. We sought to evaluate its use in a mouse obesity model characterized by myofiber atrophy.
METHODS
We applied a prediction algorithm, ie, the least absolute shrinkage and selection operator (LASSO), to surface, needle array, and ex vivo EIM data from db/db and wild-type mice and assessed myofiber cross-sectional area (CSA) histologically and triglyceride (TG) content biochemically.
RESULTS
EIM data from all three modalities provided acceptable predictions of myofiber CSA with average root mean square error (RMSE) of 15% in CSA (ie, ±209 μm
CONCLUSIONS
EIM combined with a predictive algorithm provides reasonable estimates of myofiber CSA and TG content without the need for biopsy.
Identifiants
pubmed: 33063867
doi: 10.1002/mus.27095
pmc: PMC8891989
mid: NIHMS1779160
doi:
Substances chimiques
Triglycerides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-140Subventions
Organisme : NINDS NIH HHS
ID : R01 NS091159
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Physiol Meas. 2010 Nov;31(11):1437-48
pubmed: 20834112
Biomark Med. 2015;9(11):1095-105
pubmed: 26526897
Prostaglandins Leukot Essent Fatty Acids. 2007 Jan;76(1):9-18
pubmed: 17098406
PLoS One. 2012;7(9):e45004
pubmed: 23028733
Muscle Nerve. 2008 Sep;38(3):1128-32
pubmed: 18642375
Longev Healthspan. 2014 Dec 01;3(1):9
pubmed: 25520782
Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):
pubmed: 30291145
J Strength Cond Res. 2013 Aug;27(8):2219-24
pubmed: 23222084
PLoS One. 2019 Oct 1;14(10):e0223265
pubmed: 31574117
Muscle Nerve. 2019 Dec;60(6):801-810
pubmed: 31531861
Nat Protoc. 2013 Jun;8(6):1149-54
pubmed: 23702831
Physiol Meas. 2006 Oct;27(10):953-9
pubmed: 16951455
Physiol Meas. 2018 May 22;39(5):055005
pubmed: 29616985
Phys Med Biol. 2014 Feb 21;59(4):1027-45
pubmed: 24504153
Ann Clin Transl Neurol. 2020 Jan;7(1):4-14
pubmed: 31876124
Physiol Meas. 2009 Dec;30(12):1415-27
pubmed: 19887721
Muscle Nerve. 2016 Sep;54(3):460-8
pubmed: 26833551
Muscle Nerve. 2018 Nov;58(5):713-717
pubmed: 30175407
Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):485-91
pubmed: 26285066
PLoS One. 2013 Jun 06;8(6):e65976
pubmed: 23762454
Amyotroph Lateral Scler. 2012 Sep;13(5):439-45
pubmed: 22670883
Muscle Nerve. 2014 Jun;49(6):829-35
pubmed: 24752469
Geriatrics (Basel). 2018 Dec 16;3(4):
pubmed: 31011127
IEEE Trans Biomed Eng. 2019 Feb;66(2):354-364
pubmed: 29993468
Clin Neurophysiol. 2009 Aug;120(8):1534-8
pubmed: 19570710
Cell. 1996 Feb 9;84(3):491-5
pubmed: 8608603
Phys Med Biol. 2014 May 21;59(10):2369-80
pubmed: 24743385
Neurobiol Dis. 2016 Mar;87:116-23
pubmed: 26733414
Muscle Nerve. 2015 Jan;51(1):49-55
pubmed: 24752678
Neurology. 2010 Aug 10;75(6):526-31
pubmed: 20697104
Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E592-605
pubmed: 24425761
Muscle Nerve. 2018 Feb 24;:
pubmed: 29476692
Clin Neurophysiol. 2006 Jun;117(6):1244-8
pubmed: 16644269
Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E635-43
pubmed: 22761161
J Cheminform. 2014 Mar 29;6(1):10
pubmed: 24678909
Am J Pathol. 2011 Jul;179(1):12-22
pubmed: 21703390
IEEE Trans Biomed Eng. 2019 Jun;66(6):1761-1768
pubmed: 30387720
Phys Med Rehabil Clin N Am. 2012 Feb;23(1):1-10, ix
pubmed: 22239869
Nature. 1996 Feb 15;379(6566):632-5
pubmed: 8628397
Future Sci OA. 2018 Apr 16;4(6):FSO308
pubmed: 30057785
Ageing Res Rev. 2017 May;35:200-221
pubmed: 27702700
J Nutr Health Aging. 2011 Jan;15(1):10-5
pubmed: 21267515
J Appl Physiol (1985). 2000 Jul;89(1):104-10
pubmed: 10904041
Clin Neurophysiol. 2011 Dec;122(12):2505-11
pubmed: 21612980
Curr Neurol Neurosci Rep. 2017 Sep 20;17(11):86
pubmed: 28933017
PLoS One. 2017 Oct 19;12(10):e0185614
pubmed: 29049394
Sci Data. 2019 Apr 18;6(1):37
pubmed: 31000708