Cohesion between pulmonary artery and bronchus after immune checkpoint inhibitor therapy in a lung cancer patient.
Non-small cell lung cancer
programmed death-ligand 1
surgery
Journal
Thoracic cancer
ISSN: 1759-7714
Titre abrégé: Thorac Cancer
Pays: Singapore
ID NLM: 101531441
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
05
09
2020
revised:
23
09
2020
accepted:
25
09
2020
pubmed:
17
10
2020
medline:
20
11
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Immunotherapy targeting programmed death-1 or programmed death-ligand 1 has become the standard of care for advanced non-small cell lung cancer (NSCLC). Several recent clinical trials have investigated the efficacy of immune checkpoint inhibitors (ICIs) as neoadjuvant treatment for early NSCLC. However, the safety and feasibility of pulmonary resection after ICIs remain unclear. We herein report a patient in whom cohesion between the left main pulmonary artery and left upper bronchus was found during left upper lobectomy following neoadjuvant ICI combined with chemotherapy. After both central and peripheral sides of the left main pulmonary artery were clamped with the aim of controlling hemorrhage in case of vascular injury, the left main pulmonary artery and left upper bronchus were divided and individually cut with staplers. The thoracoscopic procedure was otherwise uneventful. The patient was discharged from our hospital with no postoperative complications. Thoracic surgeons should anticipate the possible need for management of cohesion between a pulmonary artery and bronchus in patients who have received immune checkpoint inhibitors preoperatively.
Identifiants
pubmed: 33063937
doi: 10.1111/1759-7714.13697
pmc: PMC7705917
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3605-3608Subventions
Organisme : Japanese Foundation for Multidisciplinary Treatment of Cancer
ID : Japanese Foundation for Multidisciplinary Treatmen
Informations de copyright
© 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
Références
Ann Thorac Cardiovasc Surg. 2015;21(1):78-80
pubmed: 24835920
N Engl J Med. 2018 Nov 22;379(21):2040-2051
pubmed: 30280635
N Engl J Med. 2018 May 24;378(21):1976-1986
pubmed: 29658848
Ann Thorac Surg. 2017 Sep;104(3):e217-e218
pubmed: 28838509
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Lancet. 2017 Jan 21;389(10066):255-265
pubmed: 27979383
Ann Thorac Surg. 2018 Jul;106(1):178-183
pubmed: 29550207
N Engl J Med. 2018 May 31;378(22):2078-2092
pubmed: 29658856
Clin Lung Cancer. 2020 Jul;21(4):e265-e269
pubmed: 32184051