The effect of combined curcumin-mediated photodynamic therapy and artificial skin on Staphylococcus aureus-infected wounds in rats.
Artificial skin
Blue light
Curcumin
Photochemotherapy
Wound healing
Journal
Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
04
12
2019
accepted:
12
10
2020
pubmed:
17
10
2020
medline:
22
7
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Healing wounds represent a major public health problem, mainly when it is infected. Besides that, the antibiotics misuse and overuse favor the development of bacterial resistance. This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) combined with artificial skin on disinfection of infected skin wound in rats. Twenty-four Wistar rats were randomly distributed into 4 groups (n = 6): (i) control-untreated; (ii) aPDT-treated with curcumin-mediated aPDT (blue light); (iii) artificial skin-treated with artificial skin alcohol-based; and (iv) aPDT plus artificial skin-treated with aPDT associated with artificial skin alcohol-based. For the in vivo model, a full-thickness biopsy with 0.80 cm was performed in order to inoculate the microorganism Staphylococcus aureus (ATCC 25923). The aPDT was performed with a curcumin gel and a blue LED light (450 nm, 80 mW/cm
Identifiants
pubmed: 33064262
doi: 10.1007/s10103-020-03160-6
pii: 10.1007/s10103-020-03160-6
doi:
Substances chimiques
Photosensitizing Agents
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1219-1226Subventions
Organisme : CAPES
ID : 88887.302709/2018-00
Organisme : FAPESP
ID : 2013/14001-9
Organisme : FAPESP
ID : 2013/07276-1
Informations de copyright
© 2020. Springer-Verlag London Ltd., part of Springer Nature.
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