Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ
Administration, Oral
Analgesics, Opioid
/ chemistry
Animals
Binding Sites
Blood-Brain Barrier
/ drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Evaluation, Preclinical
Half-Life
Ligands
Male
Mice
Molecular Dynamics Simulation
Pain
/ drug therapy
Receptors, Opioid, mu
/ agonists
Receptors, sigma
/ antagonists & inhibitors
Spiro Compounds
/ chemistry
Structure-Activity Relationship
Sigma-1 Receptor
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 12 2020
24 12 2020
Historique:
pubmed:
17
10
2020
medline:
3
2
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
The synthesis and pharmacological activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the σ
Identifiants
pubmed: 33064947
doi: 10.1021/acs.jmedchem.0c01127
doi:
Substances chimiques
Analgesics, Opioid
0
Ligands
0
Receptors, Opioid, mu
0
Receptors, sigma
0
Spiro Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM