Effects of Ovariectomy and Sex Hormone Replacement on Numbers of Kisspeptin-, Neurokinin B- and Dynorphin A-immunoreactive Neurons in the Arcuate Nucleus of the Hypothalamus in Obese and Diabetic Rats.
KNDy neurons
diabetes
high-fat diet
ovariectomy
reproduction
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
14
05
2020
revised:
17
09
2020
accepted:
02
10
2020
pubmed:
17
10
2020
medline:
15
5
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
KNDy neurons co-expressing kisspeptin (KP), neurokinin B (NKB) and dynorphin A (DYN A) in the arcuate nucleus of the hypothalamus (ARC) are key regulators of reproduction. Their activity is influenced by metabolic and hormonal signals. Previously, we have shown that orchidectomy alters the KP-, NKB-, and DYN A-immunoreactivity in the high-fat diet-induced (HFD) obesity and diabetes type 2 (DM2) models. Considering the potential sex difference in the response of KNDy neurons, we have hypothesized that ovariectomy (OVX) and post-ovariectomy replacement with estradiol (OVX+E
Identifiants
pubmed: 33065232
pii: S0306-4522(20)30653-9
doi: 10.1016/j.neuroscience.2020.10.003
pii:
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Kisspeptins
0
Gonadotropin-Releasing Hormone
33515-09-2
Dynorphins
74913-18-1
Neurokinin B
86933-75-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
184-196Informations de copyright
Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.