Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients.
CD24
biomarker
cetuximab
colorectal cancer
single nucleotide polymorphism
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Oct 2020
13 Oct 2020
Historique:
received:
16
08
2020
revised:
03
10
2020
accepted:
06
10
2020
entrez:
17
10
2020
pubmed:
18
10
2020
medline:
18
10
2020
Statut:
epublish
Résumé
Cetuximab, an IgG1 EGFR-directed antibody, promotes antibody-dependent cell-mediated cytotoxicity. We hypothesized that single-nucleotide polymorphisms (SNPs) in immune regulatory pathways may predict outcomes in patients with metastatic colorectal cancer treated with cetuximab-based regimens. A total of 924 patients were included: 105 received cetuximab in IMCL-0144 and cetuximab/irinotecan in GONO-ASL608LIOM01 (training cohort), 225 FOLFIRI/cetuximab in FIRE-3 (validation cohort 1), 74 oxaliplatin/cetuximab regimens in JACCRO CC-05/06 (validation cohort 2), and 520 FOLFIRI/bevacizumab in FIRE-3 and TRIBE (control cohorts). Twelve SNPs in five genes (
Identifiants
pubmed: 33065994
pii: cancers12102947
doi: 10.3390/cancers12102947
pmc: PMC7601940
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P30CA014089-27S1
Pays : United States
Organisme : Dhont Family Foundation
ID : -
Organisme : Wunderglo Foundation
ID : -
Organisme : Daniel Butler Research Fund
ID : -
Organisme : German Cancer Aid (Mildred-Scheel Foundation)
ID : -
Références
PLoS One. 2014 Dec 26;9(12):e115848
pubmed: 25541686
Br J Clin Pharmacol. 2012 May;73(5):776-85
pubmed: 22486600
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13427-32
pubmed: 18765800
Int J Biol Markers. 2014 Mar 24;29(1):e49-54
pubmed: 24474454
Oncol Lett. 2016 Sep;12(3):1868-1876
pubmed: 27602116
Cancer Immunol Res. 2016 Apr;4(4):366-74
pubmed: 26817995
Eur J Cancer. 2012 Aug;48(12):1774-80
pubmed: 22305465
J Clin Oncol. 2007 Aug 20;25(24):3712-8
pubmed: 17704420
Mol Ther. 2013 Jan;21(1):91-100
pubmed: 22990672
Inflamm Bowel Dis. 2010 May;16(5):795-803
pubmed: 19998456
Nat Med. 2016 Jun;22(6):624-31
pubmed: 27135741
Stem Cells. 2013 Sep;31(9):2024-30
pubmed: 23553902
Clin Cancer Res. 2008 Dec 1;14(23):7884-95
pubmed: 19047118
J Clin Oncol. 2009 Mar 1;27(7):1122-9
pubmed: 19164213
Lancet Oncol. 2014 Sep;15(10):1065-75
pubmed: 25088940
J Clin Oncol. 2015 Mar 1;33(7):692-700
pubmed: 25605843
Cell Death Dis. 2014 Mar 27;5:e1149
pubmed: 24675467
Gut. 2001 Feb;48(2):176-85
pubmed: 11156637
Clin Immunol. 2004 Oct;113(1):47-55
pubmed: 15380529
Nucleic Acids Res. 2008 Jan;36(Database issue):D820-4
pubmed: 17986460
Clin Cancer Res. 2007 Mar 1;13(5):1552-61
pubmed: 17332301
Gut. 2015 Feb;64(2):353-4
pubmed: 23704317
Cancer Sci. 2017 Mar;108(3):455-460
pubmed: 28075526
J Clin Invest. 2007 Sep;117(9):2570-82
pubmed: 17710230
World J Gastroenterol. 2015 May 21;21(19):6052-9
pubmed: 26019472
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W600-5
pubmed: 19417063
Cytogenet Cell Genet. 1995;70(1-2):119-25
pubmed: 7736776
Pharmacogenomics J. 2015 Dec;15(6):521-9
pubmed: 25752522
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):473-8
pubmed: 17197414
J Exp Med. 2004 Oct 18;200(8):1083-9
pubmed: 15477346
World J Gastrointest Oncol. 2016 Feb 15;8(2):222-30
pubmed: 26909137
Clin Cancer Res. 2006 Feb 15;12(4):1144-51
pubmed: 16489067
Gastroenterology. 2013 Aug;145(2):416-25.e1-4
pubmed: 23669411
J Clin Oncol. 2006 Oct 20;24(30):4914-21
pubmed: 17050875
Cell Physiol Biochem. 2017;44(3):1038-1050
pubmed: 29179214
Clin Cancer Res. 2013 Mar 1;19(5):1126-38
pubmed: 23209031
Cancer Res. 2010 Jul 15;70(14):5942-52
pubmed: 20634405
Br J Cancer. 2012 Jan 3;106(1):141-7
pubmed: 22108515
Oncogene. 2013 Jun 6;32(23):2873-81
pubmed: 22797062
Breast Cancer Res Treat. 2013 Feb;137(3):927-37
pubmed: 23314606
Nature. 2011 Jan 20;469(7330):415-8
pubmed: 21113151
Pharmacogenomics J. 2014 Apr;14(2):142-50
pubmed: 23817222
Nat Rev Microbiol. 2011 May;9(5):356-68
pubmed: 21423246
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17073-8
pubmed: 18952840
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Eur J Cancer. 2010 Jun;46(9):1703-11
pubmed: 20399639
Cancer Sci. 2007 Aug;98(8):1275-80
pubmed: 17498200
N Engl J Med. 2014 Oct 23;371(17):1609-18
pubmed: 25337750
Breast Cancer Res Treat. 2012 Apr;132(3):819-31
pubmed: 21960110
Cancer Sci. 2010 May;101(5):1080-8
pubmed: 20331636
Int J Cancer. 2014 May 1;134(9):2146-55
pubmed: 24136682
Tumour Biol. 2014 Sep;35(9):8927-32
pubmed: 24894672
Cancer Treat Rev. 2018 Feb;63:48-60
pubmed: 29223828
Mol Cancer Ther. 2012 Aug;11(8):1829-37
pubmed: 22675042