Preliminary Study on β3-Adrenoreceptor as Predictor Marker of Relapse in Ewing Sarcoma Patients.
circulating tumour cells
ewing sarcoma
β3-adrenergic receptors
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
13 Oct 2020
13 Oct 2020
Historique:
received:
11
09
2020
revised:
08
10
2020
accepted:
10
10
2020
entrez:
17
10
2020
pubmed:
18
10
2020
medline:
18
10
2020
Statut:
epublish
Résumé
Ewing sarcoma (EWS) is a paediatric aggressive malignant tumour of bones and soft tissues. Multidisciplinary chemotherapies, surgical resection, and radiation represent the only strategies counteracting the disease, however spreading and relapse of disease still remain a clinical issue. Circulating tumour cells (CTCs) are an important feature of EWS but the prognostic significance has not been, yet, clarified. CTCs have been found both in patients with localized disease and in those who recur or metastasize. The identification of markers that can detect recurrences and metastasis remains an important challenge for research. Unfortunately, even most of patients with localized cancer relapsed and the reason has not yet been fully understood. In this clinical study on EWS patients, we evaluated the expression of CD99 antigen and beta-3 adrenergic receptor (β3-AR) on CTCs and bioptic derived cells by flow cytometry. The preliminary data revealed a higher β3-AR expression on cells derived from metastatic or relapsed patients, suggesting a role for the β3-AR as a possible predictive maker of disease recurrence in both patients with metastatic and localized disease.
Identifiants
pubmed: 33066095
pii: biomedicines8100413
doi: 10.3390/biomedicines8100413
pmc: PMC7600453
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Mol Pharmacol. 2007 Nov;72(5):1359-68
pubmed: 17717109
Mol Cell Biol. 1994 May;14(5):3230-41
pubmed: 8164678
Med Oncol. 2014 Aug;31(8):109
pubmed: 25008066
Adv Exp Med Biol. 2016;890:57-74
pubmed: 26703799
Biol Blood Marrow Transplant. 2018 Jun;24(6):1223-1231
pubmed: 29410181
Am J Hematol. 2017 Jan;92(1):50-55
pubmed: 27733010
Curr Opin Oncol. 1999 Jul;11(4):275-84
pubmed: 10416880
Oncotarget. 2017 Aug 24;8(44):77292-77308
pubmed: 29100387
J Clin Oncol. 2003 Jan 1;21(1):85-91
pubmed: 12506175
Br J Pharmacol. 2019 Jul;176(14):2496-2508
pubmed: 30471093
Oxid Med Cell Longev. 2018 Nov 13;2018:6816508
pubmed: 30538804
J Clin Oncol. 2015 Sep 20;33(27):3036-46
pubmed: 26304893
Int J Cancer. 1995 Apr 21;64(2):135-9
pubmed: 7542227
Br J Pharmacol. 2010 Jul;160(5):1048-61
pubmed: 20590599
J Clin Oncol. 1998 May;16(5):1707-11
pubmed: 9586882
Cancers (Basel). 2016 Jan 05;8(1):
pubmed: 26742077
Cancer Treat Rev. 2015 May;41(5):391-400
pubmed: 25869102
Oncotarget. 2017 Jan 24;8(4):6446-6460
pubmed: 28031536
Cancer Lett. 2007 Aug 28;254(1):1-10
pubmed: 17250957
Cancer Manag Res. 2018 May 10;10:1089-1114
pubmed: 29785138
Cancer Manag Res. 2018 Jan 09;10:49-60
pubmed: 29386915
Cancer Epidemiol. 2013 Feb;37(1):29-33
pubmed: 22959474
Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9
pubmed: 14730417
J Cell Commun Signal. 2018 Mar;12(1):55-68
pubmed: 29305692
Br J Pharmacol. 2019 Jul;176(14):2509-2524
pubmed: 30874296
Cancer Res. 2009 Sep 15;69(18):7140-50
pubmed: 19738075
J Pediatr Hematol Oncol. 2008 Aug;30(8):575-83
pubmed: 18799933
Nat Genet. 1999 Oct;23(2):222-7
pubmed: 10508522
Clin Cancer Res. 2004 Oct 15;10(20):6897-904
pubmed: 15501967
Sarcoma. 2011;2011:352580
pubmed: 22135504
Indian J Orthop. 2010 Oct;44(4):369-77
pubmed: 20924476
Acta Chir Scand Suppl. 1955;201:1-70
pubmed: 14387468
Int J Obes (Lond). 2010 Oct;34 Suppl 1:S36-42
pubmed: 20935665
Annu Rev Med. 1997;48:307-16
pubmed: 9046964
Eur J Cancer. 2006 Jan;42(1):91-6
pubmed: 16326096
J Mol Diagn. 2015 May;17(3):209-24
pubmed: 25908243
Oncotarget. 2015 Mar 10;6(7):4615-32
pubmed: 25474135
Nature. 2006 Aug 17;442(7104):742-3
pubmed: 16915262
J Mol Med (Berl). 2013 Dec;91(12):1407-19
pubmed: 23907236
Oncogene. 2020 Jan;39(2):368-384
pubmed: 31477835
Int J Mol Sci. 2019 Apr 30;20(9):
pubmed: 31052299
Cancer. 2015 Oct 1;121(19):3444-51
pubmed: 26301456
J Immunol. 1998 Jul 15;161(2):749-54
pubmed: 9670951