Cashew
antioxidant
cashew nuts
cerulein-induced acute pancreatitis
inflammation
polyphenols
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
14 Oct 2020
14 Oct 2020
Historique:
received:
07
09
2020
revised:
10
10
2020
accepted:
11
10
2020
entrez:
17
10
2020
pubmed:
18
10
2020
medline:
18
10
2020
Statut:
epublish
Résumé
One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. To investigate the effect of cashew ( Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung. Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein.
Sections du résumé
BACKGROUND
BACKGROUND
One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated.
METHODS
METHODS
To investigate the effect of cashew (
RESULTS
RESULTS
Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung.
CONCLUSIONS
CONCLUSIONS
Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein.
Identifiants
pubmed: 33066525
pii: antiox9100992
doi: 10.3390/antiox9100992
pmc: PMC7602264
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Mediators Inflamm. 2016;2016:5460302
pubmed: 27672241
Phytother Res. 2016 Apr;30(4):663-70
pubmed: 26833708
J Nutr Metab. 2020 May 4;2020:6980754
pubmed: 32455002
Antioxidants (Basel). 2020 Jun 10;9(6):
pubmed: 32532064
Curr Opin Crit Care. 2002 Apr;8(2):158-63
pubmed: 12386518
Surg Infect (Larchmt). 2008 Dec;9(6):573-8
pubmed: 19216669
Gut Liver. 2008 Sep;2(2):74-80
pubmed: 20485614
J Agric Food Chem. 2010 Nov 10;58(21):11250-6
pubmed: 20929236
J Chromatogr A. 2010 Nov 19;1217(47):7411-7
pubmed: 20961547
Br J Nutr. 2018 Jan;119(1):30-41
pubmed: 29355095
J Pineal Res. 2004 Jan;36(1):1-9
pubmed: 14675124
Br J Pharmacol. 2019 Dec;176(23):4446-4461
pubmed: 31347703
Oxid Med Cell Longev. 2020 Feb 17;2020:4063562
pubmed: 32148650
Pancreas. 2009 Nov;38(8):954-67
pubmed: 19672210
Oxid Med Cell Longev. 2018 Apr 18;2018:3753562
pubmed: 29849888
JGH Open. 2019 Apr 17;3(6):450-455
pubmed: 31832543
Mol Pharmacol. 2016 Nov;90(5):549-561
pubmed: 27625036
Pak J Pharm Sci. 2012 Jan;25(1):111-5
pubmed: 22186317
Front Cell Neurosci. 2019 Jan 07;12:516
pubmed: 30666189
Pharmacol Res. 2017 Sep;123:83-92
pubmed: 28676456
Gastroenterology. 2011 Jul;141(1):358-69
pubmed: 21439959
Int J Mol Med. 2011 Jan;27(1):53-61
pubmed: 21069254
Biochem Biophys Res Commun. 2016 Sep 9;478(1):93-100
pubmed: 27453338
Gastroenterology Res. 2009 Feb;2(1):20-28
pubmed: 27956946
Cell Death Dis. 2019 Feb 12;10(2):128
pubmed: 30755589
Oxid Med Cell Longev. 2016;2016:7864150
pubmed: 27847555
Klin Khir. 2000;(1):54-7
pubmed: 10859926
Nutrients. 2020 Mar 20;12(3):
pubmed: 32245085
Intensive Care Med. 2007 May;33(5):880-893
pubmed: 17384932
World J Gastroenterol. 2010 Jul 21;16(27):3411-7
pubmed: 20632444
Antioxidants (Basel). 2020 Aug 22;9(9):
pubmed: 32842687
Molecules. 2018 Feb 12;23(2):
pubmed: 29439533
World J Gastroenterol. 2014 Dec 14;20(46):17324-9
pubmed: 25516643
World J Gastroenterol. 2007 Apr 7;13(13):1966-9
pubmed: 17461498
Transl Res. 2014 Oct;164(4):259-69
pubmed: 25152324
Inflammopharmacology. 2013 Feb;21(1):37-46
pubmed: 22274733
Inflammopharmacology. 2012 Jun;20(3):127-50
pubmed: 22271002
Lab Invest. 2002 Oct;82(10):1359-68
pubmed: 12379770
Cell Tissue Res. 2004 Mar;315(3):321-9
pubmed: 14747941
Biomed Res Int. 2018 Nov 28;2018:1294951
pubmed: 30622955
Oxid Med Cell Longev. 2019 Jul 14;2019:9372182
pubmed: 31396308
J Inflamm Res. 2015 Jan 16;8:15-27
pubmed: 25653548
Oxid Med Cell Longev. 2019 Nov 6;2019:2197017
pubmed: 31781326
Curr Gastroenterol Rep. 2004 Apr;6(2):99-103
pubmed: 15191686
J Ethnopharmacol. 2004 Dec;95(2-3):139-42
pubmed: 15507326
Eur J Pharmacol. 1998 Dec 11;363(1):57-63
pubmed: 9877082
Exp Biol Med (Maywood). 2015 Dec;240(12):1648-55
pubmed: 25819683
Oxid Med Cell Longev. 2020 Mar 23;2020:9410952
pubmed: 32273949
Biochem Pharmacol. 2006 Nov 30;72(11):1439-52
pubmed: 16920072
Nat Rev Immunol. 2019 Aug;19(8):477-489
pubmed: 31036962
Arthritis Res Ther. 2013;15(6):R192
pubmed: 24246048
Adv Immunol. 2020;145:55-93
pubmed: 32081200
Shock. 2019 May;51(5):557-568
pubmed: 30124598
Drug Dev Res. 2015 May;76(3):143-51
pubmed: 25959135
Int J Pancreatol. 2001;29(3):163-71
pubmed: 12067220
Environ Mol Mutagen. 2003;41(5):360-9
pubmed: 12802807
Cell. 2014 Mar 13;156(6):1193-1206
pubmed: 24630722
J Ethnopharmacol. 2019 May 23;236:345-353
pubmed: 30872173
Ann Surg. 1998 Jan;227(1):86-94
pubmed: 9445115
JAMA. 2001 Mar 7;285(9):1178-82
pubmed: 11231747
Molecules. 2016 Aug 19;21(8):
pubmed: 27548136
PLoS One. 2019 Dec 12;14(12):e0225736
pubmed: 31830056
Mol Cell Biochem. 2014 Nov;396(1-2):269-80
pubmed: 25060908
Obesity (Silver Spring). 2006 Dec;14(12):2224-35
pubmed: 17189550
Int J Mol Med. 2017 Aug;40(2):427-437
pubmed: 28586010
Nat Rev Drug Discov. 2018 Sep;17(9):688
pubmed: 30116046
Clin Oral Investig. 2016 Jan;20(1):43-56
pubmed: 25914047
World J Gastroenterol. 2003 Nov;9(11):2565-9
pubmed: 14606098
J Med Food. 2011 Jul-Aug;14(7-8):792-8
pubmed: 21612456
Eur J Intern Med. 2011 Apr;22(2):141-6
pubmed: 21402243
Lancet. 2007 May 5;369(9572):1553-1564
pubmed: 17482987
Oxid Med Cell Longev. 2014;2014:360438
pubmed: 24999379
Pancreas. 2020 Mar;49(3):420-428
pubmed: 32132514
Int J Mol Sci. 2020 Jun 13;21(12):
pubmed: 32545788
Evid Based Complement Alternat Med. 2015;2015:601503
pubmed: 26229543
Int J Dev Neurosci. 2017 Oct;61:58-67
pubmed: 28663041
Med Klin (Munich). 1995 Jan 15;90 Suppl 1:36-41
pubmed: 7715583
Shock. 2003 Dec;20(6):544-50
pubmed: 14625479
Mol Aspects Med. 2011 Aug;32(4-6):234-46
pubmed: 22020111
Life Sci. 2020 Jan 1;240:117084
pubmed: 31759040
Biomed Pharmacother. 2019 Apr;112:108629
pubmed: 30798137
PLoS One. 2015 May 11;10(5):e0125556
pubmed: 25961820
Antioxidants (Basel). 2020 Jul 24;9(8):
pubmed: 32722199
J Food Sci. 2011 Jun-Jul;76(5):C768-74
pubmed: 22417425
Food Res Int. 2020 Jan;127:108628
pubmed: 31882076
Free Radic Res. 2008 Apr;42(4):289-96
pubmed: 18404527
Cell Death Dis. 2017 Mar 16;8(3):e2685
pubmed: 28300832