Developmental and reproductive safety evaluation of AV7909 anthrax vaccine candidate in rats.
AV7909
anthrax vaccine
developmental toxicity
rat
reproductive toxicity
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
05
06
2020
revised:
21
07
2020
accepted:
17
09
2020
pubmed:
18
10
2020
medline:
19
8
2021
entrez:
17
10
2020
Statut:
ppublish
Résumé
The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to support licensure for use in women of childbearing potential. Groups of first generation (F
Identifiants
pubmed: 33067910
doi: 10.1002/bdr2.1815
pmc: PMC7821328
doi:
Substances chimiques
Anthrax Vaccines
0
Antibodies, Neutralizing
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-42Subventions
Organisme : Department of Health and Human Services, Biomedical Advanced Research and Development Authority
ID : HHSO100201600030C
Informations de copyright
© 2020 The Authors. Birth Defects Research published by Wiley Periodicals LLC.
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