Development of an antigen-capture enzyme-linked immunosorbent assay for diagnosis of Aleutian mink disease virus.
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
26
04
2020
accepted:
06
09
2020
pubmed:
18
10
2020
medline:
22
1
2021
entrez:
17
10
2020
Statut:
ppublish
Résumé
Aleutian mink disease (AMD), caused by Aleutian mink disease virus (AMDV), is a very important infectious disease of mink. Currently, elimination of antibody- or antigen-positive animals is the most successful strategy for eradicating AMD, but the claw-cutting method of blood sampling is difficult to perform and painful for the animal. In this study, we aimed to establish an antigen capture enzyme-linked immunosorbent assay (AC-ELISA) method for the efficient detection of AMDV antigens using fecal samples. A purified mouse monoclonal antibody (mAb) was used as the capture antibody, and a rabbit polyclonal antibody (pAb) was used as the detection antibody. The assay was optimized by adjusting a series of parameters. Using a cutoff value of 0.205, the limit of detection of the AC-ELISA for strain AMDV-G antigen was 2 μg/mL, and there was no cross-reaction with other mink viruses. The intra- and inter-assay standard deviations were below 0.046, and the correlation of variance (CV) values were 1.24-7.12% when testing fecal samples. Compared with conventional PCR results, the specificity and sensitivity were 91.5% and 90.6%, respectively, and the concordance rate between the two methods was 91.1%.
Identifiants
pubmed: 33068192
doi: 10.1007/s00705-020-04850-w
pii: 10.1007/s00705-020-04850-w
doi:
Substances chimiques
Antibodies, Viral
0
Antigens
0
Capsid Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-90Subventions
Organisme : Young Scientists Fund
ID : 31700140
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