Biclonal lymphoproliferative disorders: another association with NOTCH1-mutated chronic lymphocytic leukaemias.
Biclonal lymphoproliferative disorder
Chronic lymphocytic leukaemia
NOTCH1 mutation
Richter’s transformation
Journal
Irish journal of medical science
ISSN: 1863-4362
Titre abrégé: Ir J Med Sci
Pays: Ireland
ID NLM: 7806864
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
09
08
2019
accepted:
23
09
2020
pubmed:
18
10
2020
medline:
5
10
2021
entrez:
17
10
2020
Statut:
ppublish
Résumé
Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We hypothesised that the incidence of NOTCH1 mutations in CLL with a second LPD may be increased, because the mutation occurs early in leukaemogenesis, permitting clonal divergence. We identified 19 patients with biclonal LPD at diagnosis: 11 with CLL and a second LPD (group A) and 8 with a second distinct CLL (group B). NOTCH1 mutation analysis was performed and clinical outcome investigated. Ten of 19 (52%) were NOTCH1 mutated: 5 in group A (45%) and 5 in group B (62.5%) with a favourable clinical outcome observed among this cohort with 28.7 (range 1-99) months of follow-up. In conclusion, we identified a significant (52%) incidence of NOTCH1 mutations in CLL in the context of biclonal LPD, associated with an indolent clinical course.
Identifiants
pubmed: 33068240
doi: 10.1007/s11845-020-02386-1
pii: 10.1007/s11845-020-02386-1
doi:
Substances chimiques
NOTCH1 protein, human
0
Receptor, Notch1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1087-1094Informations de copyright
© 2020. Royal Academy of Medicine in Ireland.
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