Biological effects of inhaled hydraulic fracturing sand dust. II. Particle characterization and pulmonary effects 30 d following intratracheal instillation.
Air Pollutants, Occupational
/ adverse effects
Animals
Disease Models, Animal
Dust
Hydraulic Fracking
/ methods
Inhalation Exposure
/ adverse effects
Lung
/ drug effects
Male
Occupational Exposure
/ adverse effects
Pneumonia
/ chemically induced
Quartz
/ adverse effects
Rats
Rats, Sprague-Dawley
Sand
/ chemistry
Silicon Dioxide
/ adverse effects
Silicosis
/ etiology
Trachea
/ drug effects
Fracking sand dust
MIN-U-SIL®
Particle characterization
Rat model
Silica
Journal
Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
16
07
2020
revised:
07
10
2020
accepted:
10
10
2020
pubmed:
18
10
2020
medline:
12
1
2021
entrez:
17
10
2020
Statut:
ppublish
Résumé
Hydraulic fracturing ("fracking") is used in unconventional gas drilling to allow for the free flow of natural gas from rock. Sand in fracking fluid is pumped into the well bore under high pressure to enter and stabilize fissures in the rock. In the process of manipulating the sand on site, respirable dust (fracking sand dust, FSD) is generated. Inhalation of FSD is a potential hazard to workers inasmuch as respirable crystalline silica causes silicosis, and levels of FSD at drilling work sites have exceeded occupational exposure limits set by OSHA. In the absence of any information about its potential toxicity, a comprehensive rat animal model was designed to investigate the bioactivities of several FSDs in comparison to MIN-U-SIL® 5, a respirable α-quartz reference dust used in previous animal models of silicosis, in several organ systems (Fedan, J.S., Toxicol Appl Pharmacol. 00, 000-000, 2020). The present report, part of the larger investigation, describes: 1) a comparison of the physico-chemical properties of nine FSDs, collected at drilling sites, and MIN-U-SIL® 5, a reference silica dust, and 2) a comparison of the pulmonary inflammatory responses to intratracheal instillation of the nine FSDs and MIN-U-SIL® 5. Our findings indicate that, in many respects, the physico-chemical characteristics, and the biological effects of the FSDs and MIN-U-SIL® 5 after intratracheal instillation, have distinct differences.
Identifiants
pubmed: 33068622
pii: S0041-008X(20)30408-7
doi: 10.1016/j.taap.2020.115282
pmc: PMC7818045
mid: NIHMS1652759
pii:
doi:
Substances chimiques
Air Pollutants, Occupational
0
Dust
0
Sand
0
Quartz
14808-60-7
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115282Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Inhal Toxicol. 2002 Apr;14(4):349-67
pubmed: 12028809
Exp Lung Res. 1986;10(4):385-99
pubmed: 3013607
Exp Lung Res. 1987;13(2):205-22
pubmed: 2822380
Toxicol Appl Pharmacol. 2020 Dec 1;408:115280
pubmed: 33065154
Toxicol Appl Pharmacol. 1990 Oct;106(1):88-101
pubmed: 2174581
Toxicol Appl Pharmacol. 2020 Nov 1;406:115242
pubmed: 32931794
Toxicol Appl Pharmacol. 2020 Dec 15;409:115330
pubmed: 33166545
Lab Invest. 1987 Nov;57(5):546-54
pubmed: 2824924
J Environ Pathol Toxicol Oncol. 2001;20 Suppl 1:109-18
pubmed: 11570668
Toxicol Appl Pharmacol. 2020 Dec 15;409:115300
pubmed: 33141058
Part Fibre Toxicol. 2015 Apr 26;12:10
pubmed: 25927223
Toxicol Appl Pharmacol. 2020 Dec 15;409:115329
pubmed: 33181145
Am J Respir Crit Care Med. 2016 Mar 15;193(6):673-80
pubmed: 26513613
Lancet. 2012 May 26;379(9830):2008-18
pubmed: 22534002
Inhal Toxicol. 2017 Jun;29(7):322-339
pubmed: 28967277
Am J Ind Med. 2004 Oct;46(4):323-6
pubmed: 15376224
Toxicol Pathol. 2014;42(3):472-86
pubmed: 24178583
Toxicol Sci. 2000 May;55(1):24-35
pubmed: 10788556
Toxicol Appl Pharmacol. 1994 Dec;129(2):235-42
pubmed: 7992313
Mol Cell Biochem. 2002 May-Jun;234-235(1-2):177-84
pubmed: 12162431
Am J Ind Med. 2005 Jul;48(1):10-5
pubmed: 15940714
Toxicol Appl Pharmacol. 2020 Dec 15;409:115284
pubmed: 33068619
Ann Occup Hyg. 1988;32(4):553-6
pubmed: 3228266
J Occup Environ Hyg. 2013;10(7):347-56
pubmed: 23679563
Am J Respir Cell Mol Biol. 1990 Apr;2(4):381-90
pubmed: 2157474
Arch Pathol Lab Med. 1988 Jul;112(7):673-720
pubmed: 2838005
J Toxicol Environ Health. 1995 Jul;45(3):349-65
pubmed: 7609007
Environ Health Perspect. 1990 Apr;85:15-23
pubmed: 2166657
J Environ Pathol Toxicol Oncol. 2001;20 Suppl 1:1-14
pubmed: 11570667
Toxicol Sci. 2004 Jun;79(2):370-80
pubmed: 15056817
Toxicol Appl Pharmacol. 2020 Dec 1;408:115256
pubmed: 33007384
Toxicol Appl Pharmacol. 2020 Dec 1;408:115281
pubmed: 33065155
J Toxicol Environ Health A. 2008;71(8):521-32
pubmed: 18338287
Am J Ind Med. 2005 Jul;48(1):1-9
pubmed: 15940718
Ann Occup Hyg. 2005 Jul;49(5):367-73
pubmed: 15728107
Environ Health Perspect. 1983 Sep;51:141-6
pubmed: 6315354
J Pharm Sci. 2008 Jun;97(6):2041-4
pubmed: 17847072