Quantitating Interfraction Target Dynamics During Concurrent Chemoradiation for Glioblastoma: A Prospective Serial Imaging Study.

Adult Aged Brain Neoplasms / diagnostic imaging Chemoradiotherapy / methods Dose Fractionation, Radiation Female Gadolinium Glioblastoma / diagnostic imaging Humans Magnetic Resonance Imaging / methods Male Middle Aged Prospective Studies Radiotherapy, Image-Guided / methods Tumor Burden / radiation effects Young Adult

Journal

International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616

Informations de publication

Date de publication:
01 03 2021
Historique:
received: 11 08 2020
revised: 18 09 2020
accepted: 05 10 2020
pubmed: 18 10 2020
medline: 22 7 2021
entrez: 17 10 2020
Statut: ppublish

Résumé

Magnetic resonance image (MRI) guided radiation therapy has the potential to improve outcomes for glioblastoma by adapting to tumor changes during radiation therapy. This study quantifies interfraction dynamics (tumor size, position, and geometry) based on sequential magnetic resonance imaging scans obtained during standard 6-week chemoradiation. Sixty-one patients were prospectively imaged with gadolinium-enhanced T1 (T1c) and T2/FLAIR axial sequences at planning (Fx0), fraction 10 (Fx10), fraction 20 (Fx20), and 1 month after the final fraction of chemoradiation therapy (P1M). Gross tumor volumes (GTVs) and clinical target volumes (CTVs) were contoured at all time points. Target dynamics were quantified by absolute volume (V), volume relative to Fx0 (V Median volumes at Fx0, Fx10, Fx20, and P1M for the GTV were 18.4 cm Clinically meaningful tumor dynamics were observed during chemoradiation therapy for glioblastoma, supporting evaluation of daily MRI guided radiation therapy and treatment plan adaptation.

Identifiants

DOI: 10.1016/j.ijrobp.2020.10.002 PMID: 33068687
pubmed: 33068687
pii: S0360-3016(20)34386-8
doi: 10.1016/j.ijrobp.2020.10.002
pii:
doi:

Substances chimiques

Gadolinium AU0V1LM3JT

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

736-746

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

James Stewart (J)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada.

Arjun Sahgal (A)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Young Lee (Y)

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Department of Medical Physics, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada.

Hany Soliman (H)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Chia-Lin Tseng (CL)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Jay Detsky (J)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Zain Husain (Z)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Ling Ho (L)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada.

Sunit Das (S)

Division of Neurosurgery and Centre for Ethics, St. Michael's Hospital, Toronto, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Hospital, Toronto, Canada; Division of Neurosurgery, University of Toronto, Toronto, Canada.

Pejman Jabehdar Maralani (PJ)

Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Nir Lipsman (N)

Division of Neurosurgery, University of Toronto, Toronto, Canada; Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Greg Stanisz (G)

Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics University of Toronto, Toronto, Canada; Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland.

James Perry (J)

Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

Hanbo Chen (H)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada.

Eshetu G Atenafu (EG)

Department of Biostatistics, University Health Network, University of Toronto, Toronto, Canada.

Mikki Campbell (M)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada.

Angus Z Lau (AZ)

Department of Physical Sciences, Sunnybrook Research Institute, Toronto, Canada; Department of Medical Biophysics University of Toronto, Toronto, Canada.

Mark Ruschin (M)

Department of Radiation Oncology, University of Toronto, Toronto, Canada; Department of Medical Physics, Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada.

Sten Myrehaug (S)

Department of Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address: sten.myrehaug@sunnybrook.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Chimioradiothérapie › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Dosimétrie en radiothérapie › Fractionnement de la dose d'irradiation › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Gadolinium › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie guidée par l'image › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › Quantitating Interfraction Target Dynamics...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Quantitating Interfraction Target Dynamics...