Real-World Effectiveness and Safety of Tofacitinib in Crohn's Disease and IBD-U: A Multicenter Study From the TROPIC Consortium.

Crohn Disease / drug therapy Humans Inflammatory Bowel Diseases / drug therapy Piperidines Pyrimidines / adverse effects Pyrroles / adverse effects

Journal

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
ISSN: 1542-7714
Titre abrégé: Clin Gastroenterol Hepatol
Pays: United States
ID NLM: 101160775

Informations de publication

Date de publication:
10 2021
Historique:
received: 12 07 2020
revised: 09 10 2020
accepted: 12 10 2020
pubmed: 18 10 2020
medline: 5 10 2021
entrez: 17 10 2020
Statut: ppublish

Résumé

The safety and efficacy of tofacitinib in Crohn's disease (CD) has been studied in 2 phase II trials in patients with moderate-to-severe CD with no new safety signals observed, but no significant difference from placebo in the primary efficacy endpoint of clinical response.

Identifiants

DOI: 10.1016/j.cgh.2020.10.025 PMID: 33068786 PMC: PMC8044250
pubmed: 33068786
pii: S1542-3565(20)31438-5
doi: 10.1016/j.cgh.2020.10.025
pmc: PMC8044250
mid: NIHMS1638415
pii:
doi:

Substances chimiques

Piperidines 0
Pyrimidines 0
Pyrroles 0
tofacitinib 87LA6FU830

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2207-2209.e3

Subventions

Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109384
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK111995
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States

Informations de copyright

Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

Références

Rheumatology (Oxford). 2018 Sep 1;57(9):1651-1660
pubmed: 29893926
Clin Gastroenterol Hepatol. 2021 Aug;19(8):1592-1601.e3
pubmed: 32629130
Aliment Pharmacol Ther. 2019 Feb;49(3):265-276
pubmed: 30663107
Gastroenterology. 2018 Oct;155(4):1079-1089.e3
pubmed: 29958857
Gut. 2017 Jun;66(6):1049-1059
pubmed: 28209624
Clin Gastroenterol Hepatol. 2014 Sep;12(9):1485-93.e2
pubmed: 24480677

Auteurs

Marc Fenster (M)

Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

Quazim A Alayo (QA)

Division of Gastroenterology and Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri; Division of Internal Medicine, St. Luke's Hospital, St. Louis, Missouri.

Aava Khatiwada (A)

Division of Gastroenterology and Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri.

Wenfei Wang (W)

University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois.

Christina Dimopoulos (C)

Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Alexandra Gutierrez (A)

Division of Gastroenterology and Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri.

Matthew A Ciorba (MA)

Division of Gastroenterology and Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri.

George P Christophi (GP)

Division of Gastroenterology and Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri; Steward Center for Inflammatory Bowel Diseases, Rockledge, Florida; University of Central Florida College of Medicine, Orlando, Florida.

Robert P Hirten (RP)

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Christina Ha (C)

Division of Digestive and Liver Diseases, Cedars Sinai Medical Center, Los Angeles, California.

Poonam Beniwal-Patel (P)

Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Benjamin L Cohen (BL)

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Gastroenterology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio.

Gaurav Syal (G)

Division of Digestive and Liver Diseases, Cedars Sinai Medical Center, Los Angeles, California.

Andres Yarur (A)

Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Anish Patel (A)

Division of Gastroenterology, Brooke Army Medical Center, Fort Sam Houston, Texas.

Jean-Frederic Colombel (JF)

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Joel Pekow (J)

University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois.

Ryan C Ungaro (RC)

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

David T Rubin (DT)

University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois.

Parakkal Deepak (P)

Division of Gastroenterology and Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St. Louis, Missouri. Electronic address: deepak.parakkal@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › Real-World Effectiveness and Safety of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Real-World Effectiveness and Safety of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Real-World Effectiveness and Safety of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Real-World Effectiveness and Safety of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Real-World Effectiveness and Safety of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Real-World Effectiveness and Safety of...