Cognitive impairment in Parkinson's disease: A clinical and pathophysiological overview.
Parkinson’s disease
basal forebrain
cholinergic fibers
cognitive dysfunction
dementia
prefrontal cortex
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
12
09
2019
revised:
16
09
2020
accepted:
08
10
2020
pubmed:
18
10
2020
medline:
15
5
2021
entrez:
17
10
2020
Statut:
ppublish
Résumé
Cognitive dysfunction in Parkinson's disease (PD) has received increasing attention, and, together with other non-motor symptoms, exert a significant functional impact in the daily lives of patients. This article aims to compile and briefly summarize selected published data about clinical features, cognitive evaluation, biomarkers, and pathophysiology of PD-related dementia (PDD). The literature search included articles indexed in the MEDLINE/PubMed database, published in English, over the last two decades. Despite significant progress on clinical criteria and cohort studies for PD-mild cognitive impairment (PD-MCI) and PDD, there are still knowledge gaps about its exact molecular and pathological basis. Here we overview the scientific literature on the role of functional circuits, neurotransmitter systems (monoaminergic and cholinergic), basal forebrain, and brainstem nuclei dysfunction in PD-MCI. Correlations between neuroimaging and cerebrospinal fluid (CSF) biomarkers, clinical outcomes, and pathological results are described to aid in uncovering the neurodegeneration pattern in PD-MCI and PDD.
Identifiants
pubmed: 33068906
pii: S0022-510X(20)30513-X
doi: 10.1016/j.jns.2020.117177
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
117177Informations de copyright
Copyright © 2020. Published by Elsevier B.V.