Health-related quality of life correlates with time in therapeutic range in children on anticoagulants with International Normalised Ratio self-monitoring.
Administration, Oral
Adolescent
Age Factors
Anticoagulants
/ administration & dosage
Blood Coagulation
/ drug effects
Child
Child, Preschool
Cross-Sectional Studies
Drug Monitoring
Female
Humans
International Normalized Ratio
Male
Predictive Value of Tests
Prospective Studies
Quality of Life
Self Care
Time Factors
Vitamin K
/ antagonists & inhibitors
Anti-vitamine K
Cardiac disease
Paediatrics
Pathologie cardiaque
Patient education
Pédiatrie
Quality of life
Qualité de vie
Vitamin K antagonists
Éducation thérapeutique
Journal
Archives of cardiovascular diseases
ISSN: 1875-2128
Titre abrégé: Arch Cardiovasc Dis
Pays: Netherlands
ID NLM: 101465655
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
09
2019
revised:
24
03
2020
accepted:
14
05
2020
pubmed:
19
10
2020
medline:
20
1
2021
entrez:
18
10
2020
Statut:
ppublish
Résumé
Managing oral anticoagulant therapy with vitamin K antagonists remains challenging in paediatric medicine. This study aimed to assess the correlation between time in therapeutic range and quality of life in children participating in a non-selective International Normalised Ratio self-monitoring and vitamin K antagonist education programme. Children aged from 2 to 18 years and receiving vitamin K antagonist therapy were eligible for this prospective multicentre study. Clinical and demographic data were collected. Health-related quality of life was assessed using the PedsQL™ 4.0 questionnaire. Correlations between quality of life scores and time in therapeutic range were measured. A total of 121 children were included in the study (mean age 9.6±4.9 years). Cardiac conditions were the predominant indication for vitamin K antagonists. The mean time in therapeutic range was 0.78±0.15 overall, and 0.76±0.24 over the 3-month period before quality of life assessment. The mean total quality of life score was 76.2±18 in self reports, 71.4±22 in mother reports and 73.5±19 in father reports. The time in therapeutic range correlated with the total quality of life scores in self reports (r=0.22; P=0.04), mother reports (r=0.23; P=0.02) and father reports (r=0.28; P=0.02). The time in therapeutic range predominantly correlated with school functioning in self reports (r=0.38; P=0.002) and mother reports (r=0.40; P<0.001), and with physical functioning in father reports (r=0.28; P=0.03). Time in therapeutic range correlated with quality of life in children participating in a non-selective International Normalised Ratio self-monitoring and vitamin K antagonist education programme. Regular assessment of quality of life in patient education programmes contributes towards understanding the concerns and needs of patients.
Sections du résumé
BACKGROUND
BACKGROUND
Managing oral anticoagulant therapy with vitamin K antagonists remains challenging in paediatric medicine.
AIMS
OBJECTIVE
This study aimed to assess the correlation between time in therapeutic range and quality of life in children participating in a non-selective International Normalised Ratio self-monitoring and vitamin K antagonist education programme.
METHODS
METHODS
Children aged from 2 to 18 years and receiving vitamin K antagonist therapy were eligible for this prospective multicentre study. Clinical and demographic data were collected. Health-related quality of life was assessed using the PedsQL™ 4.0 questionnaire. Correlations between quality of life scores and time in therapeutic range were measured.
RESULTS
RESULTS
A total of 121 children were included in the study (mean age 9.6±4.9 years). Cardiac conditions were the predominant indication for vitamin K antagonists. The mean time in therapeutic range was 0.78±0.15 overall, and 0.76±0.24 over the 3-month period before quality of life assessment. The mean total quality of life score was 76.2±18 in self reports, 71.4±22 in mother reports and 73.5±19 in father reports. The time in therapeutic range correlated with the total quality of life scores in self reports (r=0.22; P=0.04), mother reports (r=0.23; P=0.02) and father reports (r=0.28; P=0.02). The time in therapeutic range predominantly correlated with school functioning in self reports (r=0.38; P=0.002) and mother reports (r=0.40; P<0.001), and with physical functioning in father reports (r=0.28; P=0.03).
CONCLUSIONS
CONCLUSIONS
Time in therapeutic range correlated with quality of life in children participating in a non-selective International Normalised Ratio self-monitoring and vitamin K antagonist education programme. Regular assessment of quality of life in patient education programmes contributes towards understanding the concerns and needs of patients.
Identifiants
pubmed: 33069639
pii: S1875-2136(20)30199-6
doi: 10.1016/j.acvd.2020.05.022
pii:
doi:
Substances chimiques
Anticoagulants
0
Vitamin K
12001-79-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
811-820Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.