Oxidation specific epitopes in asthma: New possibilities for treatment.
Asthma
Oxidation specific epitopes
Oxidative stress
Oxidized phospholipids
Reactive oxygen species
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
07
2020
revised:
30
09
2020
accepted:
07
10
2020
pubmed:
19
10
2020
medline:
24
8
2021
entrez:
18
10
2020
Statut:
ppublish
Résumé
Oxidative stress is an important feature of asthma pathophysiology that is not currently targeted by any of our frontline treatments. Reactive oxygen species, generated during times of heightened oxidative stress, can damage cellular lipids causing the production of oxidation specific epitopes (OSE). OSEs are elevated in chronic inflammatory diseases and promoting their clearance by the body, through pattern recognition receptors and IgM antibodies, prevents and resolves inflammation and tissue damage in animal models. Current research on OSEs in asthma is limited. Although they are present in the lungs of people with asthma during periods of exacerbation or allergen exposure, we do not know if they are linked with disease pathobiology. This article reviews our current understanding of OSEs in asthma and explores whether targeting OSE clearance mechanisms may be a novel therapeutic intervention for asthma.
Identifiants
pubmed: 33069787
pii: S1357-2725(20)30181-3
doi: 10.1016/j.biocel.2020.105864
pii:
doi:
Substances chimiques
Epitopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105864Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.