Cryptococcal infection in HIV-infected patients with CD4
CD4(+)T-cell count
Cryptococcal antigen
Cryptococcal infection
HIV
High-income countries
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
16
07
2020
revised:
27
09
2020
accepted:
28
09
2020
pubmed:
19
10
2020
medline:
8
1
2022
entrez:
18
10
2020
Statut:
ppublish
Résumé
The World Health Organization recommends routinely screening HIV-infected patients with CD4 We determined CrAg using a lateral flow assay in banked plasma from participants in the cohort of the Spanish AIDS Research Network. Eligible patients had CD4 We included 576 patients from June 2004 to December 2017. Of these, 43 were CrAg+ for an overall prevalence of 7.5%. There were no differences depending on birthplace. The CrAg+ was independently associated with a higher mortality at eight weeks (hazard ratio (HR) 5.36, 95% confidence interval (CI) 1.46-19.56) and 6 months (HR 3.12, 95% CI 1.19-8.21). CM was reported in 10 of the 43 CrAg+ patients. There were no cases among negatives. Five patients had CM when the plasma was collected and five developed it during the follow-up. The number of subjects needed to screen to anticipate the diagnosis of one CM case was 114. The CrAg+ prevalence among HIV-infected patients with CD4
Identifiants
pubmed: 33069858
pii: S1198-743X(20)30607-8
doi: 10.1016/j.cmi.2020.09.053
pii:
doi:
Substances chimiques
Antifungal Agents
0
Antigens, Fungal
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1171.e1-1171.e7Informations de copyright
Copyright © 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.