Testicular sperm retrieval: What should we expect from the fresh and subsequent cryopreserved sperm injection?
ICSI
azoospermia
fresh
frozen-thawed
live birth rate
testicular sperm retrieval
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
29
07
2020
revised:
13
08
2020
accepted:
29
08
2020
pubmed:
19
10
2020
medline:
22
6
2021
entrez:
18
10
2020
Statut:
ppublish
Résumé
We sought to compare ICSI outcomes of cycle using fresh versus thawed TESE spermatozoa obtained during the previous fresh TESE. All consecutive couples undergoing ICSI cycles using fresh TESE spermatozoa, followed by ICSI cycle using cryopreserved sperm remaining from the previous fresh TESE procedure were included. Ovarian stimulation (OS)/laboratory variables and cycle outcome were assessed and compared between those utilising fresh versus thawed TESE spermatozoa. Seventy-five couples were evaluated, with no in-between groups differences in OS nor embryological variables. While implantation and LBR per embryo transfer were nonsignificantly higher in the frozen as compared to the fresh TESE, there was a trend towards higher LBRs per patient in the frozen TESE group. The cumulative miscarriage rate (4% versus 14.7%, p < .022 respectively) was significantly lower and the cumulative LBR (34.7% versus 16%, p < .007 respectively) was significantly higher using frozen TESE spermatozoa. Moreover, significantly higher proportion of frozen TESE sperm samples used pentoxifylline to enhance sperm motility. In conclusion, the results of ICSI cycles using frozen TESE spermatozoa are as good, or even better than using fresh TESE spermatozoa. Further studies are required to explore the factors responsible for the improved ICSI outcome, while using frozen versus fresh TESE sperm samples.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13849Informations de copyright
© 2020 Wiley-VCH GmbH.
Références
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