Effect of Dietary Sodium Modulation on Pig Adrenal Steroidogenesis and Transcriptome Profiles.

Adrenal Cortex / drug effects Aldosterone / metabolism Animals Cytochrome P-450 CYP1B1 / genetics Diet, Sodium-Restricted / methods G Protein-Coupled Inwardly-Rectifying Potassium Channels / genetics Humans Male Renin-Angiotensin System / drug effects Sodium, Dietary / administration & dosage Steroids / metabolism Swine Transcriptome / drug effects Zona Fasciculata / drug effects Zona Glomerulosa / drug effects
adrenal cortex aldosterone hydrocortisone hyperaldosteronism hypertension models, animal sodium

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 20 10 2020
medline: 4 5 2021
entrez: 19 10 2020
Statut: ppublish

Résumé

Primary aldosteronism is a frequent form of endocrine hypertension caused by aldosterone overproduction from the adrenal cortex. Regulation of aldosterone biosynthesis has been studied in rodents despite differences in adrenal physiology with humans. We, therefore, investigated pig adrenal steroidogenesis, morphology, and transcriptome profiles of the zona glomerulosa (zG) and zona fasciculata in response to activation of the renin-angiotensin-aldosterone system by dietary sodium restriction. Six-week-old pigs were fed a low- or high-sodium diet for 14 days (3 pigs per group, 0.4 g sodium/kg feed versus 6.8 g sodium/kg). Plasma aldosterone concentrations displayed a 43-fold increase (

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.120.15998 PMID: 33070662 PMC: PMC8011841
pubmed: 33070662
doi: 10.1161/HYPERTENSIONAHA.120.15998
pmc: PMC8011841
mid: NIHMS1630775
doi:

Substances chimiques

G Protein-Coupled Inwardly-Rectifying Potassium Channels 0
Sodium, Dietary 0
Steroids 0
Aldosterone 4964P6T9RB
Cytochrome P-450 CYP1B1 EC 1.14.14.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1769-1777

Subventions

Organisme : BLRD VA
ID : I01 BX004681
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144847
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115428
Pays : United States

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Auteurs

Twinkle Vohra (T)

From the Medizinische Klinik und Poliklinik IV, Klinikum der Universität München (T.V., I.-S.K., M.R., T.A.W.), Ludwig-Maximilians-Universität München, Munich, Germany.

Elisabeth Kemter (E)

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences (E.K., A.H., E.W.), Ludwig-Maximilians-Universität München, Munich, Germany.

Na Sun (N)

Research Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany (N.S., J.W., A.W.).

Britta Dobenecker (B)

Chair of Animal Nutrition and Dietetics, Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Oberschleißheim, Germany (B.D.).

Arne Hinrichs (A)

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences (E.K., A.H., E.W.), Ludwig-Maximilians-Universität München, Munich, Germany.

Jacopo Burrello (J)

Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy (J.B., T.A.W.).

Elise P Gomez-Sanchez (EP)

Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson (E.P.G.-S.).

Celso E Gomez-Sanchez (CE)

Endocrine Division, G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS (C.E.G.-S.).
Department of Pharmacology and Toxicology and Medicine, University of Mississippi Medical Center, Jackson (C.E.G.-S.).

Jun Wang (J)

Research Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany (N.S., J.W., A.W.).

Isabella-Sabrina Kinker (IS)

From the Medizinische Klinik und Poliklinik IV, Klinikum der Universität München (T.V., I.-S.K., M.R., T.A.W.), Ludwig-Maximilians-Universität München, Munich, Germany.

Daniel Teupser (D)

Institute of Laboratory Medicine, University Hospital (D.T.), Ludwig-Maximilians-Universität München, Munich, Germany.

Konrad Fischer (K)

School of Life Sciences Weihenstephan, Technical University Munich, Freising, Germany (K.F., A.S.).

Angelika Schnieke (A)

School of Life Sciences Weihenstephan, Technical University Munich, Freising, Germany (K.F., A.S.).

Mirko Peitzsch (M)

Institute of Clinical Chemistry and Laboratory Medicine (M.P., G.E.), University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.

Graeme Eisenhofer (G)

Institute of Clinical Chemistry and Laboratory Medicine (M.P., G.E.), University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
Department of Medicine III (G.E.), University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.

Axel Walch (A)

Research Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany (N.S., J.W., A.W.).

Martin Reincke (M)

From the Medizinische Klinik und Poliklinik IV, Klinikum der Universität München (T.V., I.-S.K., M.R., T.A.W.), Ludwig-Maximilians-Universität München, Munich, Germany.

Eckhard Wolf (E)

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences (E.K., A.H., E.W.), Ludwig-Maximilians-Universität München, Munich, Germany.

Tracy Ann Williams (TA)

From the Medizinische Klinik und Poliklinik IV, Klinikum der Universität München (T.V., I.-S.K., M.R., T.A.W.), Ludwig-Maximilians-Universität München, Munich, Germany.
Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy (J.B., T.A.W.).

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Classifications MeSH

questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Cortex surrénal › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 11-Hydroxycorticostéroïdes › Aldostérone › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Eucaryotes › Animaux › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-1 de cytochromes P450 › Cytochrome P-450 CYP1B1 › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime pauvre en sel › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Canaux potassiques rectifiants entrants couplés aux protéines G › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Système rénine-angiotensine › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du sodium › Sodium alimentaire › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Cortex surrénal › Zone fasciculée › Effect of Dietary Sodium Modulation on Pig...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Glandes surrénales › Cortex surrénal › Zone glomérulée › Effect of Dietary Sodium Modulation on Pig...