Understanding vaccine-elicited protective immunity against pre-erythrocytic stage malaria in endemic regions.

Animals Culicidae Disease Vectors Erythrocytes / immunology Malaria / epidemiology Malaria Vaccines
Correlates of protection Data science Immunology Malaria Systems vaccinology Vaccine

Journal

Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899

Informations de publication

Date de publication:
10 11 2020
Historique:
received: 20 04 2020
revised: 26 08 2020
accepted: 24 09 2020
pubmed: 20 10 2020
medline: 18 3 2021
entrez: 19 10 2020
Statut: ppublish

Résumé

Recent malaria vaccine trials in endemic areas have yielded disparate results compared to studies conducted in non-endemic areas. A workshop was organized to discuss the differential pre-erythrocytic stage malaria vaccine (Pre-E-Vac) efficacies and underlying protective immunity under various conditions. It was concluded that many factors, including vaccine technology platforms, host genetics or physiologic conditions, and parasite and mosquito vector variations, may all contribute to Pre-E-Vac efficacy. Cross-disciplinary approaches are needed to decipher the multi-dimensional variables that contribute to the observed vaccine hypo-responsiveness. The malaria vaccine community has an opportunity to leverage recent advances in immunology, systems vaccinology, and high dimensionality data science methodologies to generate new clinical datasets with unprecedented levels of functional resolution as well as capitalize on existing datasets for comprehensive and aggregate analyses. These approaches would help to unlock our understanding of Pre-E-Vac immunology and to translate new candidates from the laboratory to the field more predictably.

Identifiants

DOI: 10.1016/j.vaccine.2020.09.071 PMID: 33071001
pubmed: 33071001
pii: S0264-410X(20)31253-6
doi: 10.1016/j.vaccine.2020.09.071
pii:
doi:

Substances chimiques

Malaria Vaccines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7569-7577

Informations de copyright

Copyright © 2020.

Auteurs

Annie X Y Mo (AXY)

National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Service, Rockville, MD 20892, MSC 9825, USA. Electronic address: moa@niaid.nih.gov.

John Pesce (J)

National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Service, Rockville, MD 20892, MSC 9825, USA.

Alison Deckhut Augustine (AD)

National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Service, Rockville, MD 20892, MSC 9825, USA.

Jean-Luc Bodmer (JL)

Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.

Joseph Breen (J)

National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Service, Rockville, MD 20892, MSC 9825, USA.

Wolfgang Leitner (W)

National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Service, Rockville, MD 20892, MSC 9825, USA.

B Fenton Hall (BF)

National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Service, Rockville, MD 20892, MSC 9825, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Understanding vaccine-elicited protective...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › Understanding vaccine-elicited protective...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Chaîne d'infection › Vecteurs de maladies › Understanding vaccine-elicited protective...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Érythrocytes › Understanding vaccine-elicited protective...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Understanding vaccine-elicited protective...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiprotozoaires › Vaccins contre le paludisme › Understanding vaccine-elicited protective...