Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study.
intranasal delivery
morphine
naltrexone
opioids side effects
oxycodone
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
06
2020
accepted:
20
08
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
20
10
2020
Statut:
epublish
Résumé
Opioids are broad spectrum analgesics that are an integral part of the therapeutic armamentarium to combat pain in the clinical practice. Unfortunately, together with analgesia, a number of adverse effects can occur such as nausea, vomiting, constipation, gastrointestinal alterations and cognitive impairments. Naltrexone is a competitive antagonist of opioid receptors commonly used to treat opioid addiction; its oral use against agonists side effects is limited by the decrease of opioids-therapeutic efficacy and own adverse effects. The intranasal delivery of naltrexone could offer a quick and effective achievement of CNS based on extracellular mechanisms including perineural and perivascular transport. The aim of the study was to test the efficacy of intranasal low-dose naltrexone in reducing intraperitoneal morphine and oxycodone side effects in rodents. In mice, 1 μg naltrexone intranasally administered 30 min before opioids reduced cognitive impairments and motor alteration induced by 10 mg kg
Identifiants
pubmed: 33071790
doi: 10.3389/fphar.2020.576624
pmc: PMC7531600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
576624Informations de copyright
Copyright © 2020 Micheli, Di Cesare Mannelli, Lucarini, Parisio, Toti, Fiorentino, Rigamonti, Calosi and Ghelardini.
Références
Biochim Biophys Acta. 2009 Apr;1788(4):892-910
pubmed: 18983815
Jpn J Pharmacol. 1977 Feb;27(1):117-26
pubmed: 864872
Physiol Behav. 1977 Jan;18(1):125-30
pubmed: 561970
Drugs. 1988 Mar;35(3):192-213
pubmed: 2836152
J Pain Symptom Manage. 2010 Nov;40(5):734-46
pubmed: 21075272
Pain Physician. 2008 Mar;11(2 Suppl):S105-20
pubmed: 18443635
Physiol Behav. 1976 Oct;17(4):691-7
pubmed: 1034944
Am J Surg. 2001 Nov;182(5A Suppl):11S-18S
pubmed: 11755892
Drugs. 2012 Oct 1;72(14):1847-65
pubmed: 22950533
Support Care Cancer. 1997 Nov;5(6):439-44
pubmed: 9406356
Pain Med. 2009 Jan;10(1):35-42
pubmed: 18721170
Drug Alcohol Depend. 1995 Aug;39(2):151-4
pubmed: 8529534
Pain Physician. 2005 Oct;8(4):335-47
pubmed: 16850056
Peptides. 1988 Jul-Aug;9(4):915-22
pubmed: 3067224
Methods Mol Biol. 2014;1180:31-43
pubmed: 25015141
Am J Addict. 2000 Spring;9(2):113-25
pubmed: 10934573
Pain Med. 2015 Jun;16(6):1239-42
pubmed: 25643645
Histochem Cell Biol. 2008 Jul;130(1):127-40
pubmed: 18340454
Pain Physician. 2004 Oct;7(4):431-7
pubmed: 16858484
Eur J Pharm Biopharm. 2010 Feb;74(2):290-7
pubmed: 19733661
Brain Res. 2002 Mar 29;931(2):135-45
pubmed: 11897099
Clin J Pain. 2008 May;24 Suppl 10:S8-S13
pubmed: 18418226
J Pain Symptom Manage. 1996 Apr;11(4):203-17
pubmed: 8869456
Clin Pharmacol Ther. 1992 Jul;52(1):90-5
pubmed: 1623695
Neurogastroenterol Motil. 2019 May;31(5):e13563
pubmed: 30821019
J Med Toxicol. 2016 Mar;12(1):71-5
pubmed: 26546222
J Pharmacol Exp Ther. 1975 Mar;192(3):497-505
pubmed: 1168252
J Pain Symptom Manage. 2002 Jan;23(1):48-53
pubmed: 11779668
Pediatr Crit Care Med. 2006 May;7(3):252-4
pubmed: 16575353
Drugs. 2003;63(1):17-32
pubmed: 12487620
J Am Acad Dermatol. 2019 Jun;80(6):1746-1752
pubmed: 30582992
Rand Health Q. 2020 Jun 15;8(4):
pubmed: 32582471
Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:17-28
pubmed: 15357848
J Pain Palliat Care Pharmacother. 2007;21(1):15-25
pubmed: 17430825
Curr Opin Investig Drugs. 2006 Jan;7(1):81-8
pubmed: 16425675
Pharmacol Ther. 1996;69(2):103-15
pubmed: 8984506
Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):255-60
pubmed: 503253
Am Fam Physician. 2006 Oct 15;74(8):1347-54
pubmed: 17087429
Pharmacol Biochem Behav. 2003 Dec;76(3-4):525-33
pubmed: 14643852
Psychol Rep. 1967 Aug;21(1):221-4
pubmed: 6078370
Pharmacol Rev. 1953 Jun;5(2):193-230
pubmed: 13064033
Int J Pharm. 2003 Apr 14;255(1-2):87-97
pubmed: 12672605
Pain. 2004 Jan;107(1-2):41-6
pubmed: 14715387
Expert Opin Pharmacother. 2015 Feb;16(3):399-406
pubmed: 25496063
Drugs Today (Barc). 2015 Aug;51(8):479-89
pubmed: 26380386
J Pharmacol Exp Ther. 1987 Nov;243(2):492-500
pubmed: 2824748
Pain. 2000 Feb;84(2-3):121-31
pubmed: 10666516
Pain Physician. 2006 Jan;9(1):1-39
pubmed: 16700278
Clin Psychol Rev. 2000 Mar;20(2):173-89
pubmed: 10721496
J Pharm Sci. 2016 Mar;105(3):1209-20
pubmed: 26886345
Br J Pharmacol. 2015 Jul;172(13):3189-93
pubmed: 25964986