AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis.
AMPK
SNS
VMH
obesity
thermogenesis
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
07
2020
accepted:
24
08
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
4
6
2021
Statut:
epublish
Résumé
Obesity has become a global health issue, but effective therapies remain very limited. Adaptive thermogenesis promotes weight loss by dissipating energy in the form of heat, thereby representing a promising target to counteract obesity. Notably, the regulation of thermogenesis is tightly orchestrated by complex neuronal networks, especially those in the hypothalamus. Recent evidence highlights the importance of adenosine monophosphate-activated protein kinase (AMPK) within the ventromedial nucleus of the hypothalamus (VMH) in modulating thermogenesis. Various molecules, such as GLP-1, leptin, estradiol, and thyroid hormones, have been reported to act on the VMH to inhibit AMPK, which subsequently increases thermogenesis through the activation of the sympathetic nervous system (SNS). In this review, we summarize the critical role of AMPK within the VMH in the control of energy balance, focusing on its contribution to thermogenesis and the associated mechanisms.
Identifiants
pubmed: 33071984
doi: 10.3389/fendo.2020.578830
pmc: PMC7538541
doi:
Substances chimiques
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
578830Informations de copyright
Copyright © 2020 Liu, Xu and Hu.
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