Leptin Receptors in RIP-Cre
glucose metabolism
insulin deficiency
leptin
lipid metabolism
the hypothalamus
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
07
2020
accepted:
25
08
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
4
6
2021
Statut:
epublish
Résumé
Leptin is a potent endocrine hormone produced by adipose tissue and regulates a broad range of whole-body metabolism such as glucose and lipid metabolism, even without insulin. Central leptin signaling can lower hyperglycemia in insulin-deficient rodents via multiple mechanisms, including improvements of dyslipidemia. However, the specific neurons that regulate anti-dyslipidemia effects of leptin remain unidentified. Here we report that leptin receptors (LEPRs) in neurons expressing Cre recombinase driven by a short fragment of a promoter region of
Identifiants
pubmed: 33071988
doi: 10.3389/fendo.2020.588447
pmc: PMC7538546
doi:
Substances chimiques
Insulin
0
Leptin
0
Receptors, Leptin
0
Cre recombinase
EC 2.7.7.-
Integrases
EC 2.7.7.-
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
588447Subventions
Organisme : NIA NIH HHS
ID : RF1 AG061872
Pays : United States
Informations de copyright
Copyright © 2020 Singha, Palavicini, Pan, Farmer, Sandoval, Han and Fujikawa.
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