Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model.

Animals DNA Damage / immunology DNA Glycosylases / deficiency Disease Models, Animal Inflammation / chemically induced Lupus Erythematosus, Cutaneous / chemically induced Lupus Erythematosus, Systemic / chemically induced Mice Mice, Knockout Monocytes / immunology Oxidation-Reduction / drug effects Skin / immunology Terpenes / adverse effects
8-OH-dG IFN-stimulated genes Ogg1 SLE cGAS-STING pathway

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 22 04 2020
accepted: 12 08 2020
entrez: 19 10 2020
pubmed: 20 10 2020
medline: 1 5 2021
Statut: epublish

Résumé

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair mechanisms that modulate this process and govern disease progression are unclear. To gain insight into this biology, we interrogated the role of oxyguanine glycosylase 1 (OGG1), which repairs oxidized guanine 8-Oxo-2'-deoxyguanosine (8-OH-dG), in the pristane-induced mouse model of SLE.

Identifiants

DOI: 10.3389/fimmu.2020.554725 PMID: 33072095 PMC: PMC7541920
pubmed: 33072095
doi: 10.3389/fimmu.2020.554725
pmc: PMC7541920
doi:

Substances chimiques

Terpenes 0
pristane 26HZV48DT1
DNA Glycosylases EC 3.2.2.-
Ogg1 protein, mouse EC 3.2.2.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

554725

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI124211
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AR041199
Pays : United States

Informations de copyright

Copyright © 2020 Tumurkhuu, Chen, Montano, Ercan Laguna, De Los Santos, Yu, Lane, Yamashita, Markman, Blanco, Kaplan, Shimada, Crother, Ishimori, Wallace, Jefferies and Arditi.

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Auteurs

Gantsetseg Tumurkhuu (G)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Shuang Chen (S)

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Infectious and Immunological Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, United States.
David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.

Erica N Montano (EN)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Duygu Ercan Laguna (D)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Gabriela De Los Santos (G)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Jeong Min Yu (JM)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Malcolm Lane (M)

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Michifumi Yamashita (M)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Janet L Markman (JL)

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Luz P Blanco (LP)

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States.

Mariana J Kaplan (MJ)

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States.

Kenichi Shimada (K)

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Infectious and Immunological Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, United States.
David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.

Timothy R Crother (TR)

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Infectious and Immunological Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, United States.
David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.

Mariko Ishimori (M)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.

Daniel J Wallace (DJ)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.

Caroline A Jefferies (CA)

Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Moshe Arditi (M)

Division of Pediatric Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Biomedical Sciences, Infectious and Immunological Diseases Research Center (IIDRC), Cedars-Sinai Medical Center, Los Angeles, CA, United States.
David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › N-Glycosyl hydrolases › DNA Glycosylases › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Lupus érythémateux cutané › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Système tégumentaire › Peau › Oxidative DNA Damage Accelerates Skin...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Oxidative DNA Damage Accelerates Skin...