Decreased Frequency of Intestinal CD39
Adult
Aged
Aged, 80 and over
Apyrase
/ metabolism
Biomarkers
Female
Gene Expression
Humans
Immunologic Memory
Immunophenotyping
Inflammatory Bowel Diseases
/ diagnosis
Intestinal Mucosa
/ immunology
Lymphocyte Activation
Lymphocyte Count
Male
Middle Aged
Receptors, Antigen, T-Cell, gamma-delta
/ metabolism
T-Lymphocyte Subsets
/ immunology
ATP
CD39
CD73
IBD
adenosine
gut
tissue-residency
γδ+ T cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
05
2020
accepted:
13
08
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
13
5
2021
Statut:
epublish
Résumé
The ectoenzymes CD39 and CD73 play a major role in controlling tissue inflammation by regulating the balance between adenosine triphosphate (ATP) and adenosine. Still, little is known about the role of these two enzymes and ATP and its metabolites in the pathophysiology of inflammatory bowel disease (IBD). We isolated mononuclear cells from peripheral blood and lamina propria of the large intestine of patients diagnosed with IBD and of healthy volunteers. We then comprehensively analyzed the CD39 and CD73 expression patterns together with markers of activation (HLA-DR, CD38), differentiation (CCR7, CD45RA) and tissue-residency (CD69, CD103, CD49a) on CD4
Identifiants
pubmed: 33072107
doi: 10.3389/fimmu.2020.567472
pmc: PMC7541837
doi:
Substances chimiques
Biomarkers
0
Receptors, Antigen, T-Cell, gamma-delta
0
Apyrase
EC 3.6.1.5
ENTPD1 protein, human
EC 3.6.1.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
567472Informations de copyright
Copyright © 2020 Libera, Wittner, Kantowski, Woost, Eberhard, de Heer, Reher, Huber, Haag and Schulze zur Wiesch.
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