Tick Salivary Compounds for Targeted Immunomodulatory Therapy.
drug discovery
host immunity
immunomodulation
salivary glands
tick saliva
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
07
2020
accepted:
02
09
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
23
6
2021
Statut:
epublish
Résumé
Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immuno-pharmacological aspects of tick salivary compounds characterized
Identifiants
pubmed: 33072132
doi: 10.3389/fimmu.2020.583845
pmc: PMC7538779
doi:
Substances chimiques
Arthropod Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
583845Informations de copyright
Copyright © 2020 Aounallah, Bensaoud, M’ghirbi, Faria, Chmelar̆ and Kotsyfakis.
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