SABR-BRIDGE:

COVID-19 SABR lung SBRT (stereotactic body radiation therapy) lobectomy (lung) lung cancer nonsmall cell lung cancer pulmonary metastases sublobar pulmonary resection

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2020
Historique:
received: 05 07 2020
accepted: 20 08 2020
entrez: 19 10 2020
pubmed: 20 10 2020
medline: 20 10 2020
Statut: epublish

Résumé

Surgical resection is the standard-of-care approach for early-stage non-small cell lung cancer (NSCLC). Surgery is also considered an acceptable standard infit patients with oligometastatic lesions in the lungs. The COVID-19 pandemic has led to worldwide issues with access to operating room time, with patients and physicians facing uncertainty as to when surgical resection will be available, with likely delays of months. Further compounding this are concerns about increased risks of respiratory complications with lung cancer surgery during active phases of the pandemic. In this setting, many thoracic oncology teams are embracing a paradigm where stereotactic ablative radiotherapy (SABR) is used as a bridge, to provide radical-intent treatment based on a combination of immediate SABR followed by planned surgery in 3-6 months. This pragmatic approach to treatment has been named SABR-BRIDGE (Stereotactic ABlative Radiotherapy Before Resection to avoId Delay for early-stage lunG cancer or oligomEts). This term has also been applied to the pragmatic study of the outcomes of this approach. In this paper, we discuss the standards of care in treatment of early-stage (NSCLC) and pulmonary oligometastases, the impetus for the SABR-BRIDGE approach, and the controversies surrounding assessment of pathological response to neo-adjuvant radiation therapy.

Identifiants

pubmed: 33072612
doi: 10.3389/fonc.2020.580189
pmc: PMC7544973
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

580189

Informations de copyright

Copyright © 2020 Kidane, Spicer, Kim, Fiset, Abdulkarim, Malthaner and Palma.

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Auteurs

Biniam Kidane (B)

Section of Thoracic Surgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Research Institute in Oncology and Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada.

Jonathan Spicer (J)

Division of Thoracic Surgery, Department of Surgery, McGill University, Montreal, QC, Canada.
Research Institute of the McGill University Health Center, Montreal, QC, Canada.

Julian O Kim (JO)

Research Institute in Oncology and Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Department of Radiation Oncology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Pierre-Olivier Fiset (PO)

Department of Pathology, McGill University, Montreal, QC, Canada.

Bassam Abdulkarim (B)

Division of Radiation Oncology, Department of Oncology, McGill University and Cedars Cancer Center, Montreal, QC, Canada.

Richard Malthaner (R)

Division of Thoracic Surgery, Department of Surgery, Western University, London, ON, Canada.
Lawson Health Research Institute, London, ON, Canada.

David Palma (D)

Lawson Health Research Institute, London, ON, Canada.
Division of Radiation Oncology, Western University, London, ON, Canada.

Classifications MeSH