Diffuse gastric cancer: histologic, molecular, and genetic basis of disease.
Diffuse
cancer
gastric
Journal
Translational gastroenterology and hepatology
ISSN: 2415-1289
Titre abrégé: Transl Gastroenterol Hepatol
Pays: China
ID NLM: 101683450
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
12
2019
accepted:
15
01
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
20
10
2020
Statut:
epublish
Résumé
Diffuse gastric cancer (DGC) is a distinct histopathologic and molecular disease, characterized by mutations in CDH1, RHOA, and others. In addition, DGC is associated with familial syndromes, including hereditary DGC and germline mutation in CDH1. Clinically, this subtype of gastric adenocarcinoma is associated with a poor prognosis and possible resistance to available systemic therapies. An understanding of the genetic and molecular underpinnings of DGC may help inform of its clinical behavior and aid in screening, diagnosis, and response to treatment. In this review, we will review the current histologic, molecular, and genetic landscape of DGC and its relevance to clinical practice.
Identifiants
pubmed: 33073047
doi: 10.21037/tgh.2020.01.02
pii: tgh-05-2020.01.02
pmc: PMC7530323
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
52Subventions
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Informations de copyright
2020 Translational Gastroenterology and Hepatology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: Dr. Crystal Denlinger has received advisory board honoraria from Astellas, Exelixis, Bayer, Merck, Bristol Myer Squibb, Eli Lilly & Co, EMD Serono, and BeiGene. Dr. Denlinger has received institutional grant support from Array BioPharma, Amgen, Advaxis, Bristol Myer Squibb, Astra Zeneca, Sanofi, BeiGene, Merrimack Pharmaceuticals, Roche/Genentech, Macrogenics, Lycera, Zymeworks, and Agios Pharmaceuticals. Dr. Jeffrey Farma is on the data safety monitoring board for Delcath. The other authors have no conflicts of interest to declare.
Références
Clin Imaging. 2019 Jul - Aug;56:33-40
pubmed: 30870726
Surg Today. 2000;30(8):675-82
pubmed: 10955728
Clin Cancer Res. 2005 Mar 15;11(6):2229-36
pubmed: 15788671
J Clin Oncol. 2012 Jul 1;30(19):2327-33
pubmed: 22585691
Cancer Sci. 2019 Apr;110(4):1352-1363
pubmed: 30771244
Surgery. 2018 Oct;164(4):754-759
pubmed: 30145018
J Med Genet. 2019 Apr;56(4):199-208
pubmed: 30661051
Lancet. 2010 Aug 28;376(9742):687-97
pubmed: 20728210
Surg Oncol. 2012 Jun;21(2):119-23
pubmed: 21256735
Eur J Cancer Prev. 2018 Mar;27(2):124-133
pubmed: 27560662
PLoS One. 2017 Sep 18;12(9):e0183891
pubmed: 28922362
Int J Cancer. 1997 Oct 21;74(5):551-5
pubmed: 9355980
Lancet Gastroenterol Hepatol. 2018 Jul;3(7):489-498
pubmed: 29706558
Ann Surg Oncol. 1998 Dec;5(8):751-6
pubmed: 9869523
Clin Gastroenterol Hepatol. 2006 Mar;4(3):262-75
pubmed: 16527687
Nat Commun. 2018 Jun 30;9(1):2447
pubmed: 29961079
J Med Genet. 2015 Jun;52(6):361-74
pubmed: 25979631
Genet Med. 2017 Sep;19(9):1013-1021
pubmed: 28301459
Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):1945-52
pubmed: 19531677
J Clin Oncol. 2013 Dec 10;31(35):4438-44
pubmed: 24190112
Clin Cancer Res. 2016 Feb 15;22(4):971-83
pubmed: 26482039
Nat Med. 2015 May;21(5):449-56
pubmed: 25894828
J Clin Oncol. 2015 Oct 1;33(28):3130-6
pubmed: 25559811
Gut. 2013 Aug;62(8):1100-11
pubmed: 22735568
J Pathol. 2013 Mar;229(4):621-9
pubmed: 23208944
Exp Mol Med. 2018 Apr 6;50(4):6
pubmed: 29622765
Lancet Oncol. 2010 May;11(5):439-49
pubmed: 20409751
J Surg Oncol. 2019 Dec;120(7):1148-1153
pubmed: 31544969
ACG Case Rep J. 2016 Dec 7;3(4):e179
pubmed: 28008412
Int J Cancer. 2019 Nov 1;145(9):2407-2417
pubmed: 30801717
Am J Clin Nutr. 2011 Nov;94(5):1266-75
pubmed: 21993435
Arch Pathol Lab Med. 2004 Jul;128(7):765-70
pubmed: 15214826
J Gastroenterol Hepatol. 2009 Mar;24(3):354-65
pubmed: 19335785
Oncol Lett. 2019 Nov;18(5):4891-4899
pubmed: 31611999
Genomics. 1995 Mar 20;26(2):281-9
pubmed: 7601454
World J Gastrointest Endosc. 2012 Oct 16;4(10):438-47
pubmed: 23189214
BMC Cancer. 2010 Nov 30;10:659
pubmed: 21118571
Nat Commun. 2018 Mar 8;9(1):1012
pubmed: 29520031
Front Pharmacol. 2018 Dec 05;9:1421
pubmed: 30568591
Br J Cancer. 2018 Aug;119(4):424-428
pubmed: 29872148
World J Gastroenterol. 2016 May 7;22(17):4307-20
pubmed: 27158199
Eur J Surg. 1995 Aug;161(8):581-6
pubmed: 8519874
Lancet. 2014 Jan 4;383(9911):31-39
pubmed: 24094768
Acta Pathol Microbiol Scand. 1965;64:31-49
pubmed: 14320675
J Cancer. 2017 Sep 20;8(17):3396-3404
pubmed: 29151922
Lancet Oncol. 2018 Nov;19(11):1437-1448
pubmed: 30355453
Gastroenterology. 2001 Dec;121(6):1348-53
pubmed: 11729114
Eur J Cancer. 2004 Aug;40(12):1897-903
pubmed: 15288293
Nature. 1998 Mar 26;392(6674):402-5
pubmed: 9537325
Lancet Oncol. 2018 Oct;19(10):1372-1384
pubmed: 30217672
Nature. 2014 Sep 11;513(7517):202-9
pubmed: 25079317
Nat Genet. 2014 Jun;46(6):583-7
pubmed: 24816255
Nat Med. 2018 Sep;24(9):1449-1458
pubmed: 30013197
Ann Oncol. 2005 Feb;16(2):273-8
pubmed: 15668283
World J Surg. 2002 Sep;26(9):1160-5
pubmed: 12209247
Gastrointest Endosc. 2018 Feb;87(2):408-418
pubmed: 28688938
Clin Cancer Res. 2017 Jul 26;:
pubmed: 28747339
Gut. 2012 May;61(5):774-9
pubmed: 21813476
Pathol Oncol Res. 2016 Jan;22(1):197-202
pubmed: 26502923
Curr Gastroenterol Rep. 2017 Aug;19(8):36
pubmed: 28730504
JAMA Oncol. 2019 Jun 27;:
pubmed: 31246251
Gastroenterology. 2009 Dec;137(6):1976-85.e1-10
pubmed: 19732775
World J Gastroenterol. 2019 Jun 21;25(23):2878-2886
pubmed: 31249446
Oncotarget. 2018 Jun 29;9(50):29336-29350
pubmed: 30034621
Cell Mol Life Sci. 2008 Nov;65(23):3756-88
pubmed: 18726070
Clin Cancer Res. 2011 May 1;17(9):2693-701
pubmed: 21430069
Ann Surg. 2007 Jun;245(6):873-9
pubmed: 17522512
Clin Med Res. 2013 Feb;11(1):36-41
pubmed: 22723466
N Engl J Med. 2008 Jul 31;359(5):453-62
pubmed: 18669424
Gut. 2007 Jul;56(7):965-7
pubmed: 17303595
World J Gastroenterol. 2014 Mar 28;20(12):3265-86
pubmed: 24696609
BMC Cancer. 2013 Jun 10;13:281
pubmed: 23758655
Front Oncol. 2015 Sep 29;5:208
pubmed: 26484312
J Natl Cancer Inst. 2009 Apr 15;101(8):592-604
pubmed: 19351925
JAMA Oncol. 2015 Apr;1(1):23-32
pubmed: 26182300
Lancet Oncol. 2014 Oct;15(11):1224-35
pubmed: 25240821
J Med Genet. 2010 Jul;47(7):436-44
pubmed: 20591882
World J Surg. 2002 Dec;26(12):1452-7
pubmed: 12370787
Oncology. 2016;90(5):239-47
pubmed: 27046280
Lancet Oncol. 2016 Dec;17(12):1697-1708
pubmed: 27776843
J Clin Oncol. 2004 Jun 1;22(11):2069-77
pubmed: 15082726
Lancet Oncol. 2015 Feb;16(2):e60-70
pubmed: 25638682
PLoS Genet. 2014 Oct 23;10(10):e1004669
pubmed: 25340522
J Gastrointest Oncol. 2012 Sep;3(3):251-61
pubmed: 22943016
Ann Oncol. 2019 Sep 1;30(9):1487-1495
pubmed: 31240302
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
J Pathol. 2008 Nov;216(3):295-306
pubmed: 18788075
J Oncol Pract. 2018 Apr;14(4):217-224
pubmed: 29641950
Surgery. 1995 Jul;118(1):115-7
pubmed: 7604372
Biochim Biophys Acta. 2012 Dec;1826(2):297-311
pubmed: 22613680
Gastrointest Endosc. 2011 Sep;74(3):485-93
pubmed: 21741645
J Med Genet. 2018 Jul;55(7):431-441
pubmed: 29929997
Nat Genet. 2000 Sep;26(1):16-7
pubmed: 10973239
Nat Rev Clin Oncol. 2013 Nov;10(11):643-55
pubmed: 24061039
Ann Surg Oncol. 2011 Jun;18(6):1575-81
pubmed: 21431408
Ann Surg Oncol. 2007 Feb;14(2):317-28
pubmed: 17094022
J Natl Cancer Inst. 1991 May 1;83(9):640-3
pubmed: 2023282
Lancet. 2018 Jul 14;392(10142):123-133
pubmed: 29880231
Ann Intern Med. 1998 Jun 1;128(11):896-9
pubmed: 9634427
Int J Cancer. 2017 Nov 15;141(10):1950-1962
pubmed: 28718913
J Med Genet. 2006 Feb;43(2):138-42
pubmed: 15831593
J Gastrointest Oncol. 2017 Feb;8(1):148-163
pubmed: 28280619
Nat Rev Dis Primers. 2017 Jun 01;3:17036
pubmed: 28569272
Lancet. 2019 May 11;393(10184):1948-1957
pubmed: 30982686
Br J Cancer. 1999 Mar;79(9-10):1522-30
pubmed: 10188901
Lancet. 2017 Dec 2;390(10111):2461-2471
pubmed: 28993052
Gut. 2020 Jan;69(1):18-31
pubmed: 31171626
Br J Cancer. 2011 Jan 4;104(1):198-207
pubmed: 21081930