Instability of Amide Bond with Trifluoroacetic Acid (20%): Synthesis, Conformational Analysis, and Mechanistic Insights into Cleavable Amide Bond Comprising β-Troponylhydrazino Acid.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
13 Oct 2020
13 Oct 2020
Historique:
received:
05
08
2020
accepted:
17
09
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
20
10
2020
Statut:
epublish
Résumé
The instability of an amide bond with dilute trifluoroacetic acid (TFA) is a rare chemical event. The native amide bonds are stable even in the neat TFA, which is one of the reagents that releases the peptides from the solid support in the solid-supported peptide synthesis method. In the repertoire of unnatural peptidomics, α-/β-hydrazino acids and their peptides are explored for the synthesis of
Identifiants
pubmed: 33073142
doi: 10.1021/acsomega.0c03729
pmc: PMC7557997
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26141-26152Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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